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    Paip2 polyadenylate-binding protein-interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 67869, updated on 18-Sep-2024

    Summary

    Official Symbol
    Paip2provided by MGI
    Official Full Name
    polyadenylate-binding protein-interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1915119
    See related
    Ensembl:ENSMUSG00000037058 AllianceGenome:MGI:1915119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310050K10Rik
    Summary
    Enables mRNA binding activity. Acts upstream of or within several processes, including memory; negative regulation of translation; and regulation of long-term synaptic potentiation. Located in cytoplasm. Is expressed in embryo and retina. Orthologous to human PAIP2 (poly(A) binding protein interacting protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 36.3), CNS E14 (RPKM 35.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Paip2 in Genome Data Viewer
    Location:
    18 B2; 18 19.16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35731649..35750239)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35598610..35617186)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene microRNA 1949 Neighboring gene small nucleolar RNA, H/ACA box 74A Neighboring gene small nucleolar RNA host gene 4 Neighboring gene matrin 3 Neighboring gene STARR-positive B cell enhancer ABC_E9973 Neighboring gene STARR-positive B cell enhancer ABC_E5651 Neighboring gene solute carrier family 23 (nucleobase transporters), member 1 Neighboring gene STARR-seq mESC enhancer starr_44241 Neighboring gene STARR-seq mESC enhancer starr_44242 Neighboring gene marginal zone B and B1 cell-specific protein 1 Neighboring gene proline rich basic protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA regulatory element binding translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables translation repressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    polyadenylate-binding protein-interacting protein 2
    Names
    PAIP-2
    Pabp-interacting protein 2
    poly(A)-binding protein-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357470.1NP_001344399.1  polyadenylate-binding protein-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      AC121821, AI449635
      Consensus CDS
      CCDS29143.1
      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000157742.2, ENSMUST00000236020.2
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    2. NM_001357471.1NP_001344400.1  polyadenylate-binding protein-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      AC121821, AI449635
      Consensus CDS
      CCDS29143.1
      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000157456.2, ENSMUST00000236868.2
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    3. NM_001357472.1NP_001344401.1  polyadenylate-binding protein-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      AC121821, AI449635
      Consensus CDS
      CCDS29143.1
      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000157519.2, ENSMUST00000235400.2
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    4. NM_001357473.1NP_001344402.1  polyadenylate-binding protein-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      AC121821, AEKQ02058005, AI449635
      Consensus CDS
      CCDS29143.1
      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    5. NM_026420.3NP_080696.1  polyadenylate-binding protein-interacting protein 2

      See identical proteins and their annotated locations for NP_080696.1

      Status: VALIDATED

      Source sequence(s)
      AI449635, AK009909, BB842021
      Consensus CDS
      CCDS29143.1
      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000036021.9, ENSMUST00000041314.17
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      35731649..35750239
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317973.3XP_017173462.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    2. XM_030250580.2XP_030106440.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    3. XM_036161261.1XP_036017154.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000158496.2, ENSMUST00000235476.2
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    4. XM_036161263.1XP_036017156.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Related
      ENSMUSP00000157936.2, ENSMUST00000235210.2
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    5. XM_036161264.1XP_036017157.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region
    6. XM_030250581.2XP_030106441.1  polyadenylate-binding protein-interacting protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UBH5, Q9D6V8, Q9DAW7
      UniProtKB/TrEMBL
      Q3TJ84, Q3U438
      Conserved Domains (1) summary
      pfam07145
      Location:108123
      PAM2; Ataxin-2 C-terminal region