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    Lrrc28 leucine rich repeat containing 28 [ Mus musculus (house mouse) ]

    Gene ID: 67867, updated on 12-Aug-2018

    Summary

    Official Symbol
    Lrrc28provided by MGI
    Official Full Name
    leucine rich repeat containing 28provided by MGI
    Primary source
    MGI:MGI:1915689
    See related
    Ensembl:ENSMUSG00000030556 Vega:OTTMUSG00000045100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300004K21Rik; 2210012C09Rik; 2310058O11Rik
    Expression
    Biased expression in testis adult (RPKM 53.0), bladder adult (RPKM 4.5) and 11 other tissues See more
    Orthologs

    Genomic context

    See Lrrc28 in Genome Data Viewer
    Location:
    7; 7 C
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (67513410..67645333, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (74658296..74790122, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene myocyte enhancer factor 2A Neighboring gene predicted gene, 33926 Neighboring gene uncharacterized LOC108167436 Neighboring gene predicted gene, 34079 Neighboring gene predicted gene, 32983 Neighboring gene tetratricopeptide repeat domain 23 Neighboring gene predicted gene, 34140 Neighboring gene synemin, intermediate filament protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 28

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027413.1NP_081689.1  leucine-rich repeat-containing protein 28 isoform 2

      See identical proteins and their annotated locations for NP_081689.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AI663251, AK008713, AK050154
      Consensus CDS
      CCDS52269.1
      UniProtKB/TrEMBL
      Q8BWS3, Q9D7Y1
      Related
      ENSMUSP00000032775.5, OTTMUSP00000066147, ENSMUST00000032775.11, OTTMUST00000118508
      Conserved Domains (2) summary
      sd00033
      Location:2042
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:65123
      LRR_8; Leucine rich repeat
    2. NM_175124.5NP_780333.3  leucine-rich repeat-containing protein 28 isoform 1

      See identical proteins and their annotated locations for NP_780333.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI663251, BC086694
      Consensus CDS
      CCDS21351.1
      UniProtKB/Swiss-Prot
      Q3TX51
      Related
      ENSMUSP00000052177.2, OTTMUSP00000066146, ENSMUST00000053950.9, OTTMUST00000118507
      Conserved Domains (2) summary
      sd00033
      Location:4366
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:65123
      LRR_8; Leucine rich repeat

    RNA

    1. NR_028143.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, so is unlikely to make a functional protein.
      Source sequence(s)
      AI663251, AK004904, BC086694
    2. NR_028144.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, so is unlikely to make a functional protein.
      Source sequence(s)
      AI663251, BC052051, BC086694
      Related
      ENSMUST00000187953.7, OTTMUST00000118511

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      67513410..67645333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541130.3XP_006541193.1  leucine-rich repeat-containing protein 28 isoform X1

      Conserved Domains (2) summary
      sd00033
      Location:4366
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:65123
      LRR_8; Leucine rich repeat
    2. XM_006541133.2XP_006541196.2  leucine-rich repeat-containing protein 28 isoform X2

      See identical proteins and their annotated locations for XP_006541196.2

      UniProtKB/TrEMBL
      Q8BVY5
      Conserved Domains (2) summary
      sd00031
      Location:2446
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:2280
      LRR_8; Leucine rich repeat

    RNA

    1. XR_391360.3 RNA Sequence

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