Format

Send to:

Choose Destination
    • Showing Current items.

    Lrrc28 leucine rich repeat containing 28 [ Mus musculus (house mouse) ]

    Gene ID: 67867, updated on 23-Jun-2021

    Summary

    Official Symbol
    Lrrc28provided by MGI
    Official Full Name
    leucine rich repeat containing 28provided by MGI
    Primary source
    MGI:MGI:1915689
    See related
    Ensembl:ENSMUSG00000030556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300004K21Rik; 2210012C09Rik; 2310058O11Rik
    Expression
    Biased expression in testis adult (RPKM 53.0), bladder adult (RPKM 4.5) and 11 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lrrc28 in Genome Data Viewer
    Location:
    7; 7 C
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (67163158..67295084, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (67513410..67645336, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (74658296..74790122, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51462 Neighboring gene predicted gene, 33926 Neighboring gene predicted gene, 34079 Neighboring gene predicted gene, 23233 Neighboring gene predicted gene, 32983 Neighboring gene tetratricopeptide repeat domain 23 Neighboring gene predicted gene, 34140 Neighboring gene synemin, intermediate filament protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 28

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027413.1NP_081689.1  leucine-rich repeat-containing protein 28 isoform 2

      See identical proteins and their annotated locations for NP_081689.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different C-terminus, as compared to isoform 1.
      Source sequence(s)
      AI663251, AK008713, AK050154
      Consensus CDS
      CCDS52269.1
      UniProtKB/TrEMBL
      Q8BWS3, Q9D7Y1
      Related
      ENSMUSP00000032775.6, ENSMUST00000032775.12
      Conserved Domains (2) summary
      sd00033
      Location:2042
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:65123
      LRR_8; Leucine rich repeat
    2. NM_175124.5NP_780333.3  leucine-rich repeat-containing protein 28 isoform 1

      See identical proteins and their annotated locations for NP_780333.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI663251, BC086694
      Consensus CDS
      CCDS21351.1
      UniProtKB/Swiss-Prot
      Q3TX51
      Related
      ENSMUSP00000052177.3, ENSMUST00000053950.10
      Conserved Domains (2) summary
      sd00033
      Location:4366
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:65123
      LRR_8; Leucine rich repeat

    RNA

    1. NR_028143.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, so is unlikely to make a functional protein.
      Source sequence(s)
      AI663251, AK004904, BC086694
    2. NR_028144.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate, so is unlikely to make a functional protein.
      Source sequence(s)
      AI663251, BC052051, BC086694
      Related
      ENSMUST00000187953.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      67163158..67295084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541130.4XP_006541193.1  leucine-rich repeat-containing protein 28 isoform X3

      Conserved Domains (3) summary
      PRK15370
      Location:41281
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      COG4886
      Location:34157
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:4366
      LRR_RI; leucine-rich repeat [structural motif]
    2. XM_036153393.1XP_036009286.1  leucine-rich repeat-containing protein 28 isoform X2

      Conserved Domains (2) summary
      PRK15370
      Location:8290
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00033
      Location:4366
      LRR_RI; leucine-rich repeat [structural motif]
    3. XM_036153392.1XP_036009285.1  leucine-rich repeat-containing protein 28 isoform X1

      Conserved Domains (3) summary
      PRK15370
      Location:8232
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      PRK15387
      Location:132359
      PRK15387; type III secretion system effector E3 ubiquitin transferase SspH2
      sd00033
      Location:4366
      LRR_RI; leucine-rich repeat [structural motif]
    4. XM_006541133.2XP_006541196.2  leucine-rich repeat-containing protein 28 isoform X4

      See identical proteins and their annotated locations for XP_006541196.2

      UniProtKB/TrEMBL
      Q8BVY5
      Conserved Domains (2) summary
      PRK15370
      Location:24194
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00031
      Location:2446
      LRR_1; leucine-rich repeat [structural motif]

    RNA

    1. XR_391360.4 RNA Sequence

    2. XR_004934174.1 RNA Sequence

    3. XR_004934173.1 RNA Sequence

    4. XR_004934175.1 RNA Sequence

    Support Center