U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Ppp6c protein phosphatase 6, catalytic subunit [ Mus musculus (house mouse) ]

    Gene ID: 67857, updated on 26-Sep-2022

    Summary

    Official Symbol
    Ppp6cprovided by MGI
    Official Full Name
    protein phosphatase 6, catalytic subunitprovided by MGI
    Primary source
    MGI:MGI:1915107
    See related
    Ensembl:ENSMUSG00000026753 AllianceGenome:MGI:1915107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp6C; 2310003C10Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytosol. Is expressed in central nervous system; pancreas epithelium; and retina. Orthologous to human PPP6C (protein phosphatase 6 catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 11.6), bladder adult (RPKM 11.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ppp6c in Genome Data Viewer
    Location:
    2; 2 B
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (39084381..39116361, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (39194369..39226349, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene suppressor of cancer cell invasion Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene mitochondrial ribosomal protein L40 pseudogene Neighboring gene vomeronasal 2, receptor, pseudogene 2 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 6 catalytic subunit
    NP_077171.1
    XP_006498319.1
    XP_017174716.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024209.3NP_077171.1  serine/threonine-protein phosphatase 6 catalytic subunit

      See identical proteins and their annotated locations for NP_077171.1

      Status: VALIDATED

      Source sequence(s)
      AK002764, AK009104, BE634938, BY197919, CD546325
      Consensus CDS
      CCDS16017.1
      UniProtKB/Swiss-Prot
      A2ASL7, Q9CQR6
      UniProtKB/TrEMBL
      A0A6P5PAE0, A0A8C6I6K0
      Related
      ENSMUSP00000028087.4, ENSMUST00000028087.6
      Conserved Domains (1) summary
      cd07415
      Location:5289
      MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      39084381..39116361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498256.4XP_006498319.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X1

      See identical proteins and their annotated locations for XP_006498319.1

      Conserved Domains (1) summary
      cl13995
      Location:1211
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
    2. XM_017319227.3XP_017174716.1  serine/threonine-protein phosphatase 6 catalytic subunit isoform X2

      Conserved Domains (1) summary
      cl13995
      Location:45207
      MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain