Format

Send to:

Choose Destination
    • Showing Current items.

    Atg3 autophagy related 3 [ Mus musculus (house mouse) ]

    Gene ID: 67841, updated on 9-Feb-2019

    Summary

    Official Symbol
    Atg3provided by MGI
    Official Full Name
    autophagy related 3provided by MGI
    Primary source
    MGI:MGI:1915091
    See related
    Ensembl:ENSMUSG00000022663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    APG3; Apg3l; Atg3l; PC3-96; 2610016C12Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 24.2), bladder adult (RPKM 17.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Atg3 in Genome Data Viewer
    Location:
    16; 16 B5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (45158784..45188538)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (45158942..45188651)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 80 Neighboring gene solute carrier family 35, member A5 Neighboring gene B and T lymphocyte associated Neighboring gene predicted gene, 30636

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - other, organism-specific biosystem (from KEGG)
      Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Autophagy - other, conserved biosystem (from KEGG)
      Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Macroautophagy, organism-specific biosystem (from REACTOME)
      Macroautophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Atg12 transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Atg8 ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Atg8 ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-like protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular protein modification process ISO
    Inferred from Sequence Orthology
    more info
     
    macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial fragmentation involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of phagocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin-like-conjugating enzyme ATG3
    Names
    autophagy-related protein 3
    NP_080678.1
    XP_006522558.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356366.1NP_001343295.1  ubiquitin-like-conjugating enzyme ATG3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129601
      Conserved Domains (3) summary
      pfam03986
      Location:248
      Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain
      pfam03987
      Location:117178
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
      pfam10381
      Location:199222
      Autophagy_C; Autophagocytosis associated protein C-terminal
    2. NM_026402.3NP_080678.1  ubiquitin-like-conjugating enzyme ATG3 isoform 1

      See identical proteins and their annotated locations for NP_080678.1

      Status: VALIDATED

      Source sequence(s)
      AC129601
      Consensus CDS
      CCDS28194.1
      UniProtKB/Swiss-Prot
      Q9CPX6
      Related
      ENSMUSP00000023343.3, ENSMUST00000023343.3
      Conserved Domains (3) summary
      pfam03986
      Location:8133
      Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain
      pfam03987
      Location:204265
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
      pfam10381
      Location:286309
      Autophagy_C; Autophagocytosis associated protein C-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      45158784..45188538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522495.3XP_006522558.1  ubiquitin-like-conjugating enzyme ATG3 isoform X1

      Conserved Domains (3) summary
      pfam03986
      Location:248
      Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain
      pfam03987
      Location:117178
      Autophagy_act_C; Autophagocytosis associated protein, active-site domain
      pfam10381
      Location:199222
      Autophagy_C; Autophagocytosis associated protein C-terminal
    Support Center