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    Idh3a isocitrate dehydrogenase 3 (NAD+) alpha [ Mus musculus (house mouse) ]

    Gene ID: 67834, updated on 23-Jun-2021

    Summary

    Official Symbol
    Idh3aprovided by MGI
    Official Full Name
    isocitrate dehydrogenase 3 (NAD+) alphaprovided by MGI
    Primary source
    MGI:MGI:1915084
    See related
    Ensembl:ENSMUSG00000032279
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA407078; AI316514; 1110003P10Rik; 1500012E04Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 153.2), cerebellum adult (RPKM 51.8) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Idh3a in Genome Data Viewer
    Location:
    9; 9 A5.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (54493795..54511946)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (54586511..54604662)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (54434318..54452469)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Dmx-like 2 Neighboring gene SH2 domain containing 7 Neighboring gene calcium and integrin binding family member 2 Neighboring gene acyl-CoA synthetase bubblegum family member 1 Neighboring gene predicted gene, 51677 Neighboring gene predicted gene, 39341

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables isocitrate dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables isocitrate dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in NADH metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in isocitrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in isocitrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 

    General protein information

    Preferred Names
    isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    Names
    NAD(+)-specific ICDH subunit alpha
    isocitric dehydrogenase subunit alpha
    NP_083849.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029573.2NP_083849.1  isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor

      See identical proteins and their annotated locations for NP_083849.1

      Status: PROVISIONAL

      Source sequence(s)
      BC049956
      Consensus CDS
      CCDS23191.1
      UniProtKB/Swiss-Prot
      Q9D6R2
      Related
      ENSMUSP00000127526.2, ENSMUST00000167866.2
      Conserved Domains (1) summary
      TIGR00175
      Location:29362
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      54493795..54511946
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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