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    HSPA13 heat shock protein family A (Hsp70) member 13 [ Homo sapiens (human) ]

    Gene ID: 6782, updated on 5-Aug-2018

    Summary

    Official Symbol
    HSPA13provided by HGNC
    Official Full Name
    heat shock protein family A (Hsp70) member 13provided by HGNC
    Primary source
    HGNC:HGNC:11375
    See related
    Ensembl:ENSG00000155304 MIM:601100; Vega:OTTHUMG00000074261
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STCH
    Summary
    The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 23.3), thyroid (RPKM 21.7) and 25 other tissues See more
    Orthologs

    Genomic context

    See HSPA13 in Genome Data Viewer
    Location:
    21q11.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (14371115..14383188, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (15743436..15755509, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 11 Neighboring gene ATP binding cassette subfamily C member 13 (pseudogene) Neighboring gene uncharacterized LOC105369304 Neighboring gene SAM domain, SH3 domain and nuclear localization signals 1 Neighboring gene SAMSN1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with heat shock protein 70kDa family, member 13 (HSPA13) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with HSPA13; predicted interaction to occur in the endoplasmic reticulum PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
      Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
      Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity, coupled IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding involved in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to unfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum chaperone complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endoplasmic reticulum lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    intracellular membrane-bounded organelle TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    heat shock 70 kDa protein 13
    Names
    heat shock protein 70kDa family, member 13
    microsomal stress 70 protein ATPase core
    stress 70 protein chaperone, microsome-associated, 60kD
    stress 70 protein chaperone, microsome-associated, 60kDa
    stress-70 protein chaperone microsome-associated 60 kDa protein
    testis secretory sperm-binding protein Li 199a

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006948.4NP_008879.3  heat shock 70 kDa protein 13 precursor

      See identical proteins and their annotated locations for NP_008879.3

      Status: REVIEWED

      Source sequence(s)
      AA018751, AA767266, AI912654, BC036370, BE467288, BI548162, CA392315, CF141775, U04735
      Consensus CDS
      CCDS13567.1
      UniProtKB/Swiss-Prot
      P48723
      UniProtKB/TrEMBL
      A0A140VK72
      Related
      ENSP00000285667.3, OTTHUMP00000082970, ENST00000285667.3, OTTHUMT00000157815
      Conserved Domains (2) summary
      cd10237
      Location:12463
      HSPA13-like_NBD; Nucleotide-binding domain of human HSPA13 and similar proteins
      PRK13930
      Location:32442
      PRK13930; rod shape-determining protein MreB; Provisional

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

      Range
      14371115..14383188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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