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    Kat8 K(lysine) acetyltransferase 8 [ Mus musculus (house mouse) ]

    Gene ID: 67773, updated on 16-Oct-2021

    Summary

    Official Symbol
    Kat8provided by MGI
    Official Full Name
    K(lysine) acetyltransferase 8provided by MGI
    Primary source
    MGI:MGI:1915023
    See related
    Ensembl:ENSMUSG00000030801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MOF; Myst1; MYST-1; D7Ertd629e; 2010203C02Rik; 5830450F21Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 32.3), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Kat8 in Genome Data Viewer
    Location:
    7 F3; 7 69.83 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127511689..127525010)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127912517..127925838)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (135056031..135069276)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vitamin K epoxide reductase complex, subunit 1 Neighboring gene branched chain ketoacid dehydrogenase kinase Neighboring gene protease, serine 8 (prostasin) Neighboring gene protease, serine 36 Neighboring gene predicted gene, 53375 Neighboring gene fused in sarcoma

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (6)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase activity (H4-K16 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables histone acetyltransferase activity (H4-K16 specific) IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone acetyltransferase activity (H4-K16 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone acetyltransferase activity (H4-K5 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MSL complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT8
    Names
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1
    MYST histone acetyltransferase 1
    histone acetyltransferase Myst1
    lysine acetyltransferase 8
    probable histone acetyltransferase MYST1
    NP_001347628.1
    NP_080646.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360699.1NP_001347628.1  histone acetyltransferase KAT8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC149222
      Conserved Domains (1) summary
      PLN00104
      Location:6291
      PLN00104; MYST -like histone acetyltransferase; Provisional
    2. NM_026370.2NP_080646.1  histone acetyltransferase KAT8 isoform 1

      See identical proteins and their annotated locations for NP_080646.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK132000, AK146710
      Consensus CDS
      CCDS21885.1
      UniProtKB/Swiss-Prot
      Q9D1P2
      Related
      ENSMUSP00000033070.8, ENSMUST00000033070.9
      Conserved Domains (1) summary
      PLN00104
      Location:21449
      PLN00104; MYST -like histone acetyltransferase; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      127511689..127525010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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