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    Kat8 K(lysine) acetyltransferase 8 [ Mus musculus (house mouse) ]

    Gene ID: 67773, updated on 2-Oct-2018

    Summary

    Official Symbol
    Kat8provided by MGI
    Official Full Name
    K(lysine) acetyltransferase 8provided by MGI
    Primary source
    MGI:MGI:1915023
    See related
    Ensembl:ENSMUSG00000030801 Vega:OTTMUSG00000058634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MOF; Myst1; MYST-1; D7Ertd629e; 2010203C02Rik; 5830450F21Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 32.3), CNS E11.5 (RPKM 9.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Kat8 in Genome Data Viewer
    Location:
    7 F3; 7 69.83 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (127912517..127925775)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (135056031..135069276)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene vitamin K epoxide reductase complex, subunit 1 Neighboring gene branched chain ketoacid dehydrogenase kinase Neighboring gene protease, serine 8 (prostasin) Neighboring gene protease, serine 36 Neighboring gene fused in sarcoma

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetyltransferase activity (H4-K16 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to histone acetyltransferase activity (H4-K16 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone acetyltransferase activity (H4-K5 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone acetyltransferase activity (H4-K8 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    histone H4-K16 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K5 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4-K8 acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    MSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    MSL complex ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone acetyltransferase KAT8
    Names
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1
    MYST histone acetyltransferase 1
    histone acetyltransferase Myst1
    lysine acetyltransferase 8
    probable histone acetyltransferase MYST1
    NP_080646.1
    XP_006508201.1
    XP_011240184.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360699.1NP_001347628.1  histone acetyltransferase KAT8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC149222
      Conserved Domains (1) summary
      cl27485
      Location:6291
      MOZ_SAS; MOZ/SAS family
    2. NM_026370.2NP_080646.1  histone acetyltransferase KAT8 isoform 1

      See identical proteins and their annotated locations for NP_080646.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK132000, AK146710
      Consensus CDS
      CCDS21885.1
      UniProtKB/Swiss-Prot
      Q9D1P2
      Related
      ENSMUSP00000033070.7, OTTMUSP00000075073, ENSMUST00000033070.8
      Conserved Domains (1) summary
      PLN00104
      Location:21449
      PLN00104; MYST -like histone acetyltransferase; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      127912517..127925775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508138.2XP_006508201.1  histone acetyltransferase KAT8 isoform X1

      Conserved Domains (3) summary
      pfam01853
      Location:181358
      MOZ_SAS; MOZ/SAS family
      pfam11717
      Location:1957
      Tudor-knot; RNA binding activity-knot of a chromodomain
      cl17182
      Location:106373
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    2. XM_011241882.2XP_011240184.1  histone acetyltransferase KAT8 isoform X2

      Conserved Domains (1) summary
      cl27485
      Location:6291
      MOZ_SAS; MOZ/SAS family
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