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    STAT3 signal transducer and activator of transcription 3 [ Homo sapiens (human) ]

    Gene ID: 6774, updated on 27-Nov-2022

    Summary

    Official Symbol
    STAT3provided by HGNC
    Official Full Name
    signal transducer and activator of transcription 3provided by HGNC
    Primary source
    HGNC:HGNC:11364
    See related
    Ensembl:ENSG00000168610 MIM:102582; AllianceGenome:HGNC:11364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APRF; HIES; ADMIO; ADMIO1
    Summary
    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in gall bladder (RPKM 47.5), lung (RPKM 47.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STAT3 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42313324..42388442, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43169811..43244652, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40465342..40540460, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B Neighboring gene signal transducer and activator of transcription 5A Neighboring gene uncharacterized LOC102725238 Neighboring gene caveolae associated protein 1 Neighboring gene RNA, U7 small nuclear 97 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hyper-IgE recurrent infection syndrome 1
    MedGen: C4721531 OMIM: 147060 GeneReviews: STAT3 Hyper IgE Syndrome
    Compare labs
    STAT3-related early-onset multisystem autoimmune disease
    MedGen: C4014795 OMIM: 615952 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
    EBI GWAS Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
    EBI GWAS Catalog
    Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155) PubMed
    env HIV-1 gp120-induced release of IL-6 activates STAT3 in primary human monocyte-derived dendritic cells PubMed
    env HIV-1 gp120 recruits SOCS-3 through IL-10 activation for suppressing IL-6 and IL-6 dependent STAT3 in immature dentritic cells PubMed
    env HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells PubMed
    env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
    Nef nef HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells PubMed
    nef Both myristoylation and acidic cluster of Nef are essential to induce the tyrosine phosphorylation of STAT3 PubMed
    nef HIV-1 Nef induces phosphorylation of STAT3 in M2-type macrophages PubMed
    nef HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner PubMed
    nef HIV-1 Nef activates signal transducer and activator of transcription 3 (STAT3) in the granulocyte-macrophage colony-stimulating factor-independent myeloid cell line, TF-1, and in primary human macrophages PubMed
    nef HIV-1 Nef specifically activates STAT3 in primary human monocyte-derived macrophages (MDM); Nef-dependent STAT3 activation is mediated by the release of soluble factor(s), including MIP-1alpha and IL-6 PubMed
    nef HIV-1 Nef activates expression of phospho-Stat3, one of the downstream signaling pathways for cell proliferation PubMed
    nef HIV-1 Nef, through its PxxP and RR106 motifs, upregulates Src kinase activity and signal transducer and activator of transcription 3 (Stat3) phosphorylation, and activates the Ras-c-Raf-MAPK1,2 pathway in podocytes PubMed
    nef The expression of HIV-1 Nef in immature dendritic cells activates STAT3 PubMed
    Tat tat HIV-1 Tat-induced upregulation and phosphorylation of STAT3 expression results in GFAP, Egr-1 and p300 transcription and protein expression in both Tat-expressing astrocytes and HIV-infected astrocytes PubMed
    tat Expression of HIV-1 Tat upregulates the abundance of signal transducer and activator of transcription 3 (STAT3) in the nucleoli of Jurkat T-cells PubMed
    tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
    tat IL10 and STAT3 are required for HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells PubMed
    tat Ectopic expression of HIV-1 Tat induces the production of human IL-6 (huIL-6) and its receptor (huIL-6Ra) and activates STAT3 signaling; these effects are involved in Tat-mediated activation of Kaposi's sarcoma-associated herpes virus (KSHV) replication PubMed
    matrix gag HIV-1 MA recruits STAT3 to the LXR promoter region containing the STAT responsive sequence TTCAGGGAA; STAT3 mediates upregulation of NR1H3 (LXR-alpha) gene expression PubMed
    gag HIV-1 MA increases phosphorylation of STAT3 PubMed
    gag HIV-1 MA natural variant S75X upregulates the expression of STAT1 and STAT3, and induces phosphorylation of STAT1 at position S727 and STAT3 at position Y705 in Epstein-Barr virus (EBV)-infected B-lymphocytes PubMed
    gag HIV-1 MA natural variant S75X-mediated proliferation of both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes requires AKT, ERK1/2, and STAT3 pathways PubMed
    gag Treatment of human stellate cells with HIV-1 MA induces phosphorylation of STAT1 and STAT3 proteins PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ20882, MGC16063

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables primary miRNA binding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling adaptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T-helper 17 cell lineage commitment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T-helper 17 type immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in astrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to interleukin-17 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to leptin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in eating behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in energy homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in eye photoreceptor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in growth hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in growth hormone receptor signaling pathway via JAK-STAT ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in interleukin-6-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interleukin-6-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leptin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in leptin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of primary miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of stem cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interleukin-10 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-8 production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of metalloendopeptidase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of miRNA transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of miRNA-mediated gene silencing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in radial glial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in receptor signaling pathway via JAK-STAT IC
    Inferred by Curator
    more info
    PubMed 
    involved_in receptor signaling pathway via JAK-STAT TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to estradiol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to leptin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in retinal rod cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sexual reproduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in temperature homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IC
    Inferred by Curator
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    signal transducer and activator of transcription 3
    Names
    DNA-binding protein APRF
    acute-phase response factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007370.1 RefSeqGene

      Range
      5001..80171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_112

    mRNA and Protein(s)

    1. NM_001369512.1NP_001356441.1  signal transducer and activator of transcription 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC087691, L29277
      Consensus CDS
      CCDS32656.1
      UniProtKB/Swiss-Prot
      Q9BW54
      Related
      ENSP00000467985.1, ENST00000588969.5
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    2. NM_001369513.1NP_001356442.1  signal transducer and activator of transcription 3 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS32656.1
      UniProtKB/Swiss-Prot
      Q9BW54
      Related
      ENSP00000503102.1, ENST00000678044.1
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    3. NM_001369514.1NP_001356443.1  signal transducer and activator of transcription 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS32657.1
      Related
      ENSP00000503574.1, ENST00000677723.1
      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    4. NM_001369516.1NP_001356445.1  signal transducer and activator of transcription 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS32657.1
      Related
      ENSP00000503237.1, ENST00000679014.1
      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    5. NM_001369517.1NP_001356446.1  signal transducer and activator of transcription 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS59288.1
      Related
      ENSP00000503634.1, ENST00000678827.1
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    6. NM_001369518.1NP_001356447.1  signal transducer and activator of transcription 3 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS59288.1
      Related
      ENSP00000467000.1, ENST00000585517.5
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    7. NM_001369519.1NP_001356448.1  signal transducer and activator of transcription 3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS92313.1
      UniProtKB/TrEMBL
      A0A7I2V395
      Related
      ENSP00000503559.1, ENST00000677479.1
      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    8. NM_001369520.1NP_001356449.1  signal transducer and activator of transcription 3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS92313.1
      UniProtKB/TrEMBL
      A0A7I2V395
      Related
      ENSP00000503332.1, ENST00000679185.1
      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    9. NM_001384984.1NP_001371913.1  signal transducer and activator of transcription 3 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS92310.1
      UniProtKB/TrEMBL
      A0A7I2V4C8
      Related
      ENSP00000503308.1, ENST00000679166.1
      Conserved Domains (4) summary
      cd10374
      Location:526687
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cl28920
      Location:321456
      STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
    10. NM_001384985.1NP_001371914.1  signal transducer and activator of transcription 3 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Conserved Domains (4) summary
      cd10374
      Location:528689
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:291
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:113292
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:295458
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    11. NM_001384986.1NP_001371915.1  signal transducer and activator of transcription 3 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS92316.1
      UniProtKB/TrEMBL
      A0A7I2YQD2
      Related
      ENSP00000503333.1, ENST00000678905.1
      Conserved Domains (4) summary
      cd10374
      Location:559719
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321489
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    12. NM_001384987.1NP_001371916.1  signal transducer and activator of transcription 3 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS92311.1
      UniProtKB/TrEMBL
      A0A7I2V444
      Related
      ENSP00000503872.1, ENST00000678043.1
      Conserved Domains (4) summary
      cd10374
      Location:547708
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    13. NM_001384988.1NP_001371917.1  signal transducer and activator of transcription 3 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS92312.1
      UniProtKB/TrEMBL
      A0A7I2V4R3
      Related
      ENSP00000504081.1, ENST00000678535.1
      Conserved Domains (4) summary
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cl15255
      Location:554705
      SH2; Src homology 2 (SH2) domain
    14. NM_001384989.1NP_001371918.1  signal transducer and activator of transcription 3 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS92309.1
      UniProtKB/TrEMBL
      A0A7I2V552
      Related
      ENSP00000504062.1, ENST00000678674.1
      Conserved Domains (4) summary
      cd10374
      Location:522682
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16847
      Location:289452
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cl28921
      Location:109286
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
    15. NM_001384990.1NP_001371919.1  signal transducer and activator of transcription 3 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS92315.1
      UniProtKB/TrEMBL
      A0A7I2V4R2
      Related
      ENSP00000504182.1, ENST00000678572.1
      Conserved Domains (4) summary
      cd10374
      Location:559720
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321489
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    16. NM_001384991.1NP_001371920.1  signal transducer and activator of transcription 3 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Consensus CDS
      CCDS92314.1
      UniProtKB/TrEMBL
      A0A7I2YQR5
      Related
      ENSP00000504350.1, ENST00000677442.1
      Conserved Domains (4) summary
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cl15255
      Location:554706
      SH2; Src homology 2 (SH2) domain
    17. NM_001384992.1NP_001371921.1  signal transducer and activator of transcription 3 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Conserved Domains (4) summary
      cd10374
      Location:534695
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cl28920
      Location:321464
      STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
    18. NM_001384993.1NP_001371922.1  signal transducer and activator of transcription 3 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC087691, AC107993
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    19. NM_003150.4NP_003141.2  signal transducer and activator of transcription 3 isoform 2

      See identical proteins and their annotated locations for NP_003141.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC087691, AI631896, AK092965, BC000627, BC008044, BI461226, CB216860, CF454565
      Consensus CDS
      CCDS32657.1
      UniProtKB/Swiss-Prot
      P40763
      Related
      ENSP00000384943.3, ENST00000404395.3
      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    20. NM_139276.3NP_644805.1  signal transducer and activator of transcription 3 isoform 1

      See identical proteins and their annotated locations for NP_644805.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1).
      Source sequence(s)
      AC087691, AI631896, AK092965, BC008044, BC014482, BI461226, CB216860, CF454565
      Consensus CDS
      CCDS32656.1
      UniProtKB/Swiss-Prot
      P40763, Q9BW54
      Related
      ENSP00000264657.4, ENST00000264657.10
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    21. NM_213662.2NP_998827.1  signal transducer and activator of transcription 3 isoform 3

      See identical proteins and their annotated locations for NP_998827.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also called STAT3B or STAT3beta, uses an alternate splice site in the 3' coding region, resulting in an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC087691, AC107993, AI631896, AK092965, BC008044, BC014482, CB216860, CB321646, CF454565
      Consensus CDS
      CCDS59288.1
      UniProtKB/Swiss-Prot
      P40763
      Related
      ENSP00000503662.1, ENST00000677030.1
      Conserved Domains (4) summary
      cd10374
      Location:554715
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      42313324..42388442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436586.1XP_047292542.1  signal transducer and activator of transcription 3 isoform X3

    2. XM_017024973.3XP_016880462.1  signal transducer and activator of transcription 3 isoform X2

      UniProtKB/TrEMBL
      A0A7I2V395
      Conserved Domains (4) summary
      cd10374
      Location:554714
      SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
      smart00964
      Location:2120
      STAT_int; STAT protein, protein interaction domain
      cd16853
      Location:139318
      STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
      cd16847
      Location:321484
      STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    3. XM_047436585.1XP_047292541.1  signal transducer and activator of transcription 3 isoform X1

      Related
      ENSP00000373923.3, ENST00000389272.7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      43169811..43244652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)