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    Ppid peptidylprolyl isomerase D (cyclophilin D) [ Mus musculus (house mouse) ]

    Gene ID: 67738, updated on 9-Aug-2021

    Summary

    Official Symbol
    Ppidprovided by MGI
    Official Full Name
    peptidylprolyl isomerase D (cyclophilin D)provided by MGI
    Primary source
    MGI:MGI:1914988
    See related
    Ensembl:ENSMUSG00000027804
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; CYP-4; Ppidl; CYP-40; 4930564J03Rik
    Annotation information
    Note: This gene encodes a 370 aa protein that is found in the cytoplasm. In some databases, it has been labeled incorrectly as 'cyclophilin D'. This same name has also been applied to a different protein, found in the mitochondrion, which is represented by Entrez GeneID 105675, Ppif. [09 Apr 2019]
    Expression
    Broad expression in CNS E11.5 (RPKM 29.1), liver E14 (RPKM 27.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Ppid in Genome Data Viewer
    Location:
    3; 3 E3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (79498644..79511117)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79591337..79603810)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (79395311..79407572)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17359 Neighboring gene folliculin interacting protein 2 Neighboring gene RIKEN cDNA 4930589L23 gene Neighboring gene RIKEN cDNA 4930579G24 gene Neighboring gene electron transferring flavoprotein, dehydrogenase Neighboring gene relaxin/insulin-like family peptide receptor 1 Neighboring gene VISTA enhancer mm1650

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FK506 binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV-A ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase D
    Names
    40 kDa peptidyl-prolyl cis-trans isomerase
    PPIase D
    cyclophilin-40
    cytoplasmic cyclophilin D
    rotamase D
    NP_001343255.1
    NP_080628.1
    XP_006502006.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356326.1NP_001343255.1  peptidyl-prolyl cis-trans isomerase D isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113945
      Conserved Domains (3) summary
      TIGR00990
      Location:98236
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:129157
      TPR; TPR repeat [structural motif]
      cl00197
      Location:1788
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
    2. NM_026352.4NP_080628.1  peptidyl-prolyl cis-trans isomerase D isoform 1

      See identical proteins and their annotated locations for NP_080628.1

      Status: VALIDATED

      Source sequence(s)
      AC113945
      Consensus CDS
      CCDS17417.1
      UniProtKB/Swiss-Prot
      Q9CR16
      Related
      ENSMUSP00000029382.8, ENSMUST00000029382.13
      Conserved Domains (5) summary
      smart00028
      Location:277306
      TPR; Tetratricopeptide repeats
      cd01926
      Location:16182
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      sd00006
      Location:223251
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:308340
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:277338
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      79498644..79511117
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501943.4XP_006502006.1  peptidyl-prolyl cis-trans isomerase D isoform X1

      See identical proteins and their annotated locations for XP_006502006.1

      Conserved Domains (3) summary
      TIGR00990
      Location:98236
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:129157
      TPR; TPR repeat [structural motif]
      cl00197
      Location:1788
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
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