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    Ppid peptidylprolyl isomerase D (cyclophilin D) [ Mus musculus (house mouse) ]

    Gene ID: 67738, updated on 30-Sep-2018

    Summary

    Official Symbol
    Ppidprovided by MGI
    Official Full Name
    peptidylprolyl isomerase D (cyclophilin D)provided by MGI
    Primary source
    MGI:MGI:1914988
    See related
    Ensembl:ENSMUSG00000027804 Vega:OTTMUSG00000029417
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ppidl; CYP-40; 4930564J03Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 29.1), liver E14 (RPKM 27.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See Ppid in Genome Data Viewer
    Location:
    3; 3 E3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (79591389..79603650)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (79395311..79407572)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene folliculin interacting protein 2 Neighboring gene predicted gene, 36442 Neighboring gene RIKEN cDNA 4930589L23 gene Neighboring gene electron transferring flavoprotein, dehydrogenase Neighboring gene RIKEN cDNA 4930579G24 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    FK506 binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Hsp90 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-prolyl cis-trans isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to UV-A ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid droplet organization ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    protein folding IEA
    Inferred from Electronic Annotation
    more info
     
    protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitochondrial membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase D
    Names
    40 kDa peptidyl-prolyl cis-trans isomerase
    PPIase D
    cyclophilin-40
    cytoplasmic cyclophilin D
    rotamase D
    NP_080628.1
    XP_006502006.1
    XP_017175187.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356326.1NP_001343255.1  peptidyl-prolyl cis-trans isomerase D isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113945
      Conserved Domains (3) summary
      sd00006
      Location:129157
      TPR; TPR repeat [structural motif]
      cl00197
      Location:1788
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
      cl26005
      Location:98236
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    2. NM_026352.4NP_080628.1  peptidyl-prolyl cis-trans isomerase D isoform 1

      See identical proteins and their annotated locations for NP_080628.1

      Status: VALIDATED

      Source sequence(s)
      AC113945
      Consensus CDS
      CCDS17417.1
      UniProtKB/Swiss-Prot
      Q9CR16
      Related
      ENSMUSP00000029382.7, OTTMUSP00000037639, ENSMUST00000029382.12
      Conserved Domains (5) summary
      smart00028
      Location:277306
      TPR; Tetratricopeptide repeats
      cd01926
      Location:16182
      cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
      sd00006
      Location:223251
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:308340
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:277338
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      79591389..79603650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319698.1XP_017175187.1  peptidyl-prolyl cis-trans isomerase D isoform X1

      Conserved Domains (3) summary
      sd00006
      Location:129157
      TPR; TPR repeat [structural motif]
      cl00197
      Location:1788
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
      cl26005
      Location:98236
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    2. XM_006501943.2XP_006502006.1  peptidyl-prolyl cis-trans isomerase D isoform X1

      See identical proteins and their annotated locations for XP_006502006.1

      Conserved Domains (3) summary
      sd00006
      Location:129157
      TPR; TPR repeat [structural motif]
      cl00197
      Location:1788
      cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
      cl26005
      Location:98236
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
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