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    STAT1 signal transducer and activator of transcription 1 [ Homo sapiens (human) ]

    Gene ID: 6772, updated on 8-Jul-2021

    Summary

    Official Symbol
    STAT1provided by HGNC
    Official Full Name
    signal transducer and activator of transcription 1provided by HGNC
    Primary source
    HGNC:HGNC:11362
    See related
    Ensembl:ENSG00000115415 MIM:600555
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91
    Summary
    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in lymph node (RPKM 79.1), appendix (RPKM 72.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STAT1 in Genome Data Viewer
    Location:
    2q32.2
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (190968989..191014197, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (191833875..191878897, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr2.5899 Neighboring gene glutaminase Neighboring gene RAB1A pseudogene 1 Neighboring gene uncharacterized LOC105373805 Neighboring gene uncharacterized LOC107985785 Neighboring gene signal transducer and activator of transcription 4 Neighboring gene RNA, U6 small nuclear 959, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    GeneReviews: Not available
    Immunodeficiency 31a
    MedGen: C4013950 OMIM: 614892 GeneReviews: Not available
    Compare labs
    Immunodeficiency 31C
    MedGen: C3279990 OMIM: 614162 GeneReviews: Not available
    Compare labs
    Mycobacterial and viral infections, susceptibility to, autosomal recessive
    MedGen: C3151088 OMIM: 613796 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2013-09-18)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2013-09-18)

    ClinGen Genome Curation Page

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 infection upregulates basal mRNA levels of JUN, IL6, STAT1, CEBPA, RELA, and CEBPG in monocyte derived macrophages PubMed
    HIV/tuberculosis coinfection upregulates STAT1 expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with tuberculosis only) PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) upregulates STAT1 expression at 18 hours post-treatment PubMed
    env HIV-1 gp120 activates both STAT1 and STAT2 in primary human monocyte-derived dendritic cells PubMed
    env Signal transducer and activator of transcription factor 1 (STAT1) partially regulates HIV-1 gp120/HCV E2-induced caspase 3 activity PubMed
    Nef nef HIV-1 Nef-induced tyrosine-hyperphosphorylation of STAT1 is inhibited by the presence of retinoic acid in monocyte-derived DCs PubMed
    nef TRAF2 and TRAF6 proteins are required for the HIV-1 Nef-induced tyrosine phosphorylation of STAT1 and STAT2 proteins. Both myristoylation and acidic cluster of Nef are essential to induce the tyrosine phosphorylation PubMed
    nef HIV-1 Nef induces phosphorylation of STAT1 in M2-type macrophages PubMed
    nef HIV-1 Nef specifically activates both alpha and beta isoforms of the signal transducer and activator of transcription 1 (STAT1) in human monocyte-derived macrophages (MDMs) PubMed
    Tat tat HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia PubMed
    tat HIV-1 and the viral protein Tat modulate the expression of signal transducer and activator of transcription 1, 91kDa (STAT1) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including STAT-1 (p91 and p84), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
    tat HIV-1 Tat suppresses IFN-gamma-induced LC3B protein expression and autophagosome formation through Tat-mediated suppression of STAT1 phosphorylation PubMed
    tat HIV-1 Tat impairs the IFNgamma-receptor signaling pathway, in primary human monocytes, at the level of STAT1 activation via Tat-dependent induction of suppressor of cytokine signaling-2 (SOCS-2) activity PubMed
    tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
    tat HIV-1 Tat represses transcription of the LMP2 gene by competing with STAT1 (signal transducer and activator of transcription 1) for binding to IRF-1 (interferon-regulatory factor-1) at the LMP2 promoter PubMed
    Vpr vpr HIV-1 Vpr induces the phosphorylation of STAT1 at tyrosine 701 and upregulates the expression of STAT1 in human monocyte-derived macrophages PubMed
    vpr HIV-1 Vpr enhances TNF-alpha production in LPS-stimulated dendritic cells (DC). Vpr-induced TNF-alpha production in DC is through STAT1 activation PubMed
    Vpu vpu The expression of STAT1 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells PubMed
    matrix gag HIV-1 MA recruits STAT1 to the LXR promoter region containing the STAT responsive sequence TTCAGGGAA; STAT1 mediates upregulation of NR1H3 (LXR-alpha) gene expression PubMed
    gag HIV-1 MA increases phosphorylation of STAT1 PubMed
    gag HIV-1 MA natural variant S75X upregulates the expression of STAT1 and STAT3, and induces phosphorylation of STAT1 at position S727 and STAT3 at position Y705 in Epstein-Barr virus (EBV)-infected B-lymphocytes PubMed
    gag Treatment of human stellate cells with HIV-1 MA induces phosphorylation of STAT1 and STAT3 proteins PubMed
    gag Exposure of human acute monocytic leukemia cells THP-1 to HIV-1 MA activates the syndecan-2/RACK-1/Jak-1 signal pathway, leading to STAT-1 phosphorylation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686B04100

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables CCR5 chemokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cadherin binding HDA PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nuclear receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein phosphatase 2A binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tumor necrosis factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-like protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in blood circulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to interferon-beta IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in interferon-gamma-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in interferon-gamma-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in interferon-gamma-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in interleukin-27-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macrophage derived foam cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in metanephric mesenchymal cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in metanephric mesenchymal cell proliferation involved in metanephros development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation by virus of viral protein levels in host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of metanephric nephron tubule epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of defense response to virus by host IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interferon-alpha production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of mesenchymal cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of nitric-oxide synthase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in renal tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to cAMP ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to cytokine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to interferon-beta IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to peptide hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in type I interferon signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in type I interferon signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in type I interferon signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    colocalizes_with nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    signal transducer and activator of transcription 1-alpha/beta
    Names
    signal transducer and activator of transcription 1, 91kD
    signal transducer and activator of transcription 1, 91kDa
    transcription factor ISGF-3 components p91/p84

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008294.1 RefSeqGene

      Range
      5001..50215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_111

    mRNA and Protein(s)

    1. NM_001384880.1NP_001371809.1  signal transducer and activator of transcription 1-alpha/beta isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Conserved Domains (5) summary
      cd10372
      Location:537687
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cl28920
      Location:317457
      STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
      pfam12162
      Location:695719
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    2. NM_001384881.1NP_001371810.1  signal transducer and activator of transcription 1-alpha/beta isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Conserved Domains (5) summary
      cd10372
      Location:559709
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:4123
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:140315
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:319479
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:717741
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    3. NM_001384882.1NP_001371811.1  signal transducer and activator of transcription 1-alpha/beta isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Related
      ENSP00000501145.1, ENST00000673942.1
      Conserved Domains (5) summary
      cd10372
      Location:555705
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317475
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:713737
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    4. NM_001384883.1NP_001371812.1  signal transducer and activator of transcription 1-alpha/beta isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Conserved Domains (5) summary
      cd10372
      Location:524674
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      cd16845
      Location:284444
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cl28921
      Location:62280
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12162
      Location:682706
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
      pfam02865
      Location:2120
      STAT_int; STAT protein, protein interaction domain
    5. NM_001384884.1NP_001371813.1  signal transducer and activator of transcription 1-alpha/beta isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Conserved Domains (4) summary
      smart00964
      Location:4123
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:140315
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:319479
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cl15255
      Location:559655
      SH2; Src homology 2 (SH2) domain
    6. NM_001384885.1NP_001371814.1  signal transducer and activator of transcription 1-alpha/beta isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Conserved Domains (5) summary
      cd10372
      Location:504654
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16845
      Location:264424
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cl28921
      Location:138261
      STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain
      pfam12162
      Location:662686
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    7. NM_001384886.1NP_001371815.1  signal transducer and activator of transcription 1-alpha/beta isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Conserved Domains (5) summary
      cd10372
      Location:557715
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:723747
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    8. NM_001384887.1NP_001371816.1  signal transducer and activator of transcription 1-alpha/beta isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Conserved Domains (5) summary
      cd10372
      Location:526676
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cl28920
      Location:315446
      STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
      pfam12162
      Location:684708
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    9. NM_001384888.1NP_001371817.1  signal transducer and activator of transcription 1-alpha/beta isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Conserved Domains (5) summary
      cd10372
      Location:547697
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317467
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:705729
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    10. NM_001384889.1NP_001371818.1  signal transducer and activator of transcription 1-alpha/beta isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:713735
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    11. NM_001384890.1NP_001371819.1  signal transducer and activator of transcription 1-alpha/beta isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Conserved Domains (5) summary
      cd10372
      Location:527677
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:124283
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:287447
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:685709
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    12. NM_001384891.1NP_001371820.1  signal transducer and activator of transcription 1-alpha/beta isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC067945
      Conserved Domains (5) summary
      cd10372
      Location:569719
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2133
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:150325
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:329489
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:727751
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    13. NM_007315.4NP_009330.1  signal transducer and activator of transcription 1-alpha/beta isoform alpha

      See identical proteins and their annotated locations for NP_009330.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha) encodes isoform alpha.
      Source sequence(s)
      AI992149, AK292604, AK315002, BU738296, CN410740, CR749636, CR998778, EB385742
      Consensus CDS
      CCDS2309.1
      UniProtKB/Swiss-Prot
      P42224
      Related
      ENSP00000354394.4, ENST00000361099.8
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain
    14. NM_139266.3NP_644671.1  signal transducer and activator of transcription 1-alpha/beta isoform beta

      See identical proteins and their annotated locations for NP_644671.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta) is different in its 3' coding region and UTR compared to variant alpha. It encodes a protein (isoform beta) with a shorter C-terminus, when compared to isoform alpha.
      Source sequence(s)
      BX400908, CR749636, CR998778
      Consensus CDS
      CCDS42793.1
      UniProtKB/Swiss-Prot
      P42224
      Related
      ENSP00000376136.3, ENST00000392322.7
      Conserved Domains (4) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:139315
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:317566
      STAT_bind; STAT protein, DNA binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

      Range
      190968989..191014197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712718.1XP_006712781.1  signal transducer and activator of transcription 1-alpha/beta isoform X2

      See identical proteins and their annotated locations for XP_006712781.1

      UniProtKB/Swiss-Prot
      P42224
      Related
      ENSP00000438703.2, ENST00000540176.6
      Conserved Domains (5) summary
      cd10372
      Location:557707
      SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins
      smart00964
      Location:2121
      STAT_int; STAT protein, protein interaction domain
      cd16851
      Location:138313
      STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      cd16845
      Location:317477
      STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)
      pfam12162
      Location:715739
      STAT1_TAZ2bind; STAT1 TAZ2 binding domain

    RNA

    1. XR_001738915.2 RNA Sequence

      Related
      ENST00000673734.1
    2. XR_001738914.2 RNA Sequence

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