Format

Send to:

Choose Destination
    • Showing Current items.

    Nsmce1 NSE1 homolog, SMC5-SMC6 complex component [ Mus musculus (house mouse) ]

    Gene ID: 67711, updated on 5-Sep-2021

    Summary

    Official Symbol
    Nsmce1provided by MGI
    Official Full Name
    NSE1 homolog, SMC5-SMC6 complex componentprovided by MGI
    Primary source
    MGI:MGI:1914961
    See related
    Ensembl:ENSMUSG00000030750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2510027N19Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 62.5), placenta adult (RPKM 30.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nsmce1 in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125066816..125090615, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (125467644..125491443, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (132611154..132635056, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30717 Neighboring gene lysine (K)-specific demethylase 8 Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 2 pseudogene Neighboring gene interleukin 4 receptor, alpha

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of Smc5-Smc6 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Smc5-Smc6 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    non-structural maintenance of chromosomes element 1 homolog
    Names
    non-SMC element 1 homolog
    NP_001347588.2
    NP_001363939.1
    NP_001363940.1
    NP_001363941.1
    NP_080606.3
    XP_036009279.1
    XP_036009280.1
    XP_036009281.1
    XP_036009282.1
    XP_036009283.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360659.2NP_001347588.2  non-structural maintenance of chromosomes element 1 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK011011, BC049558, W80039
      Conserved Domains (2) summary
      cd16493
      Location:177221
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16162
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    2. NM_001377010.1NP_001363939.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125187
      Conserved Domains (2) summary
      cd16493
      Location:190234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    3. NM_001377011.1NP_001363940.1  non-structural maintenance of chromosomes element 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125187
      Conserved Domains (2) summary
      cd16493
      Location:190234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    4. NM_001377012.1NP_001363941.1  non-structural maintenance of chromosomes element 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125187
      Conserved Domains (2) summary
      cd16493
      Location:177221
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16162
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    5. NM_026330.4NP_080606.3  non-structural maintenance of chromosomes element 1 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK011011, BC049558
      Related
      ENSMUSP00000033006.8, ENSMUST00000033006.14
      Conserved Domains (2) summary
      cd16493
      Location:190234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      125066816..125090615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153386.1XP_036009279.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

      Conserved Domains (2) summary
      cd16493
      Location:190234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    2. XM_036153388.1XP_036009281.1  non-structural maintenance of chromosomes element 1 homolog isoform X2

      Conserved Domains (2) summary
      cd16493
      Location:177221
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16162
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    3. XM_036153390.1XP_036009283.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

      Conserved Domains (2) summary
      cd16493
      Location:190234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    4. XM_036153387.1XP_036009280.1  non-structural maintenance of chromosomes element 1 homolog isoform X1

      Conserved Domains (2) summary
      cd16493
      Location:190234
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:16175
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    5. XM_036153389.1XP_036009282.1  non-structural maintenance of chromosomes element 1 homolog isoform X3

      Conserved Domains (2) summary
      cd16493
      Location:94138
      RING-CH-C4HC3_NSE1; RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes element 1 homolog (NSE1) and similar proteins
      pfam07574
      Location:179
      SMC_Nse1; Nse1 non-SMC component of SMC5-6 complex
    Support Center