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    Hikeshi heat shock protein nuclear import factor [ Mus musculus (house mouse) ]

    Gene ID: 67669, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hikeshiprovided by MGI
    Official Full Name
    heat shock protein nuclear import factorprovided by MGI
    Primary source
    MGI:MGI:96738
    See related
    Ensembl:ENSMUSG00000062797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    l7; Hike; l(7); l7Rn6; l(7)6Rn; 0610007P06Rik; 1110002N09Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 6.9), CNS E14 (RPKM 6.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Hikeshi in Genome Data Viewer
    Location:
    7 D3; 7 50.4 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (89567893..89590446, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89918685..89941223, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (97067199..97089695, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene malic enzyme 3, NADP(+)-dependent, mitochondrial Neighboring gene predicted gene 15744 Neighboring gene coiled-coil domain containing 81 Neighboring gene Eed upstream regulatory region Neighboring gene embryonic ectoderm development Neighboring gene RIKEN cDNA E230029C05 gene Neighboring gene predicted gene, 32164

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Phenotypes

    Associated conditions

    Description Tests
    lethal, Chr 7, Rinchik 6
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein Hikeshi
    Names
    lethal gene on chromosome 7 Rinchik 6 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291286.1NP_001278215.1  protein Hikeshi isoform b

      See identical proteins and their annotated locations for NP_001278215.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK002306, BY268898, CO038997
      UniProtKB/Swiss-Prot
      Q9DD02
      Conserved Domains (1) summary
      pfam05603
      Location:1172
      DUF775; Protein of unknown function (DUF775)
    2. NM_001291287.1NP_001278216.1  protein Hikeshi isoform c

      See identical proteins and their annotated locations for NP_001278216.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC161229, AK003324, AK008604, BY268898, CD776674, CO038997
      Consensus CDS
      CCDS80748.1
      UniProtKB/Swiss-Prot
      Q9DD02
      Related
      ENSMUSP00000102856.2, ENSMUST00000075010.12
      Conserved Domains (1) summary
      pfam05603
      Location:1156
      DUF775; Protein of unknown function (DUF775)
    3. NM_001291288.1NP_001278217.1  protein Hikeshi isoform d

      See identical proteins and their annotated locations for NP_001278217.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AC161229, BC083330, BY274882, CO038997
      Consensus CDS
      CCDS80747.1
      UniProtKB/TrEMBL
      D3YU13
      Conserved Domains (1) summary
      pfam05603
      Location:796
      DUF775; Protein of unknown function (DUF775)
    4. NM_001291289.1NP_001278218.1  protein Hikeshi isoform d

      See identical proteins and their annotated locations for NP_001278218.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (d).
      Source sequence(s)
      AK003324, BY268898, CO038997
      Consensus CDS
      CCDS80747.1
      UniProtKB/TrEMBL
      D3YU13
      Related
      ENSMUST00000208357.2
      Conserved Domains (1) summary
      pfam05603
      Location:796
      DUF775; Protein of unknown function (DUF775)
    5. NM_026304.3NP_080580.1  protein Hikeshi isoform a

      See identical proteins and their annotated locations for NP_080580.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK002306, BY268898, CO038997
      Consensus CDS
      CCDS21445.1
      UniProtKB/Swiss-Prot
      Q9DD02
      Related
      ENSMUSP00000119806.2, ENSMUST00000153470.9
      Conserved Domains (1) summary
      pfam05603
      Location:1195
      DUF775; Protein of unknown function (DUF775)

    RNA

    1. NR_111916.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) shares the first exon with variant 1 and then continues into the adjacent intron. This intronless is thought to be non-protein coding.
      Source sequence(s)
      AK133534, BY268898
      Related
      ENSMUST00000207695.2
    2. NR_153788.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC161229, AC165077, AI037128

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      89567893..89590446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153385.1XP_036009278.1  protein Hikeshi isoform X1

      Conserved Domains (1) summary
      pfam05603
      Location:1156
      DUF775; Protein of unknown function (DUF775)
    2. XM_006508133.5XP_006508196.1  protein Hikeshi isoform X2

      See identical proteins and their annotated locations for XP_006508196.1

      UniProtKB/TrEMBL
      A0A140LJ25
      Related
      ENSMUSP00000147050.2, ENSMUST00000207309.2
      Conserved Domains (1) summary
      pfam05603
      Location:189
      DUF775; Protein of unknown function (DUF775)
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