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    Ctdp1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 67655, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ctdp1provided by MGI
    Official Full Name
    CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1provided by MGI
    Primary source
    MGI:MGI:1926953
    See related
    Ensembl:ENSMUSG00000033323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW553592; 4930563P03Rik
    Expression
    Ubiquitous expression in thymus adult (RPKM 3.7), ovary adult (RPKM 3.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ctdp1 in Genome Data Viewer
    Location:
    18 E3; 18 53.48 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (80407959..80476229, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (80604698..80666406, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily G, member 2 Neighboring gene RIKEN cDNA D330025C20 gene Neighboring gene predicted gene, 29967 Neighboring gene predicted gene, 30020 Neighboring gene predicted gene, 41788

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II CTD heptapeptide repeat phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    TFIIF-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Tat protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    dephosphorylation of RNA polymerase II C-terminal domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    exit from mitosis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    spindle ISO
    Inferred from Sequence Orthology
    more info
     
    spindle midzone ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RNA polymerase II subunit A C-terminal domain phosphatase
    Names
    TFIIF-associating CTD phosphatase
    NP_080571.2
    XP_006526588.1
    XP_006526589.1
    XP_011245398.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026295.3NP_080571.2  RNA polymerase II subunit A C-terminal domain phosphatase

      See identical proteins and their annotated locations for NP_080571.2

      Status: VALIDATED

      Source sequence(s)
      BC053435, BY239926
      Consensus CDS
      CCDS29368.1
      UniProtKB/Swiss-Prot
      Q7TSG2
      Related
      ENSMUSP00000038938.6, ENSMUST00000036229.12
      Conserved Domains (4) summary
      TIGR02250
      Location:177323
      FCP1_euk; FCP1-like phosphatase, phosphatase domain
      cd06850
      Location:27111
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      cd00027
      Location:637706
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam09309
      Location:706960
      FCP1_C; FCP1, C-terminal

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      80407959..80476229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526525.3XP_006526588.1  RNA polymerase II subunit A C-terminal domain phosphatase isoform X1

      Conserved Domains (4) summary
      TIGR02250
      Location:177323
      FCP1_euk; FCP1-like phosphatase, phosphatase domain
      cd06850
      Location:27111
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      cd00027
      Location:637706
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam09309
      Location:706799
      FCP1_C; FCP1, C-terminal
    2. XM_011247096.2XP_011245398.1  RNA polymerase II subunit A C-terminal domain phosphatase isoform X3

      See identical proteins and their annotated locations for XP_011245398.1

      Conserved Domains (3) summary
      TIGR02250
      Location:58204
      FCP1_euk; FCP1-like phosphatase, phosphatase domain
      cd00027
      Location:518587
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam09309
      Location:587841
      FCP1_C; FCP1, C-terminal
    3. XM_006526526.3XP_006526589.1  RNA polymerase II subunit A C-terminal domain phosphatase isoform X2

      Conserved Domains (4) summary
      TIGR02250
      Location:177323
      FCP1_euk; FCP1-like phosphatase, phosphatase domain
      cd06850
      Location:27111
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      cd00027
      Location:637706
      BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
      pfam09309
      Location:706796
      FCP1_C; FCP1, C-terminal
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