U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Nob1 NIN1/RPN12 binding protein 1 homolog [ Mus musculus (house mouse) ]

    Gene ID: 67619, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nob1provided by MGI
    Official Full Name
    NIN1/RPN12 binding protein 1 homologprovided by MGI
    Primary source
    MGI:MGI:1914869
    See related
    Ensembl:ENSMUSG00000003848 AllianceGenome:MGI:1914869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ART-4; Nob1p; Psmd8bp1; 1700021I09Rik
    Summary
    Predicted to enable RNA endonuclease activity. Acts upstream of or within visual perception. Predicted to be located in cytoplasm and nucleolus. Predicted to be part of preribosome, small subunit precursor. Is expressed in nervous system and neural retina. Orthologous to human NOB1 (NIN1 (RPN12) binding protein 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 29.2), limb E14.5 (RPKM 26.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nob1 in Genome Data Viewer
    Location:
    8 D3; 8 54.12 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (108139121..108151670, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107412489..107425038, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T cells 5 Neighboring gene predicted gene, 51546 Neighboring gene STARR-seq mESC enhancer starr_22601 Neighboring gene NAD(P)H dehydrogenase, quinone 1 Neighboring gene STARR-positive B cell enhancer ABC_E8262 Neighboring gene STARR-positive B cell enhancer ABC_E1107 Neighboring gene STARR-seq mESC enhancer starr_22606 Neighboring gene ribosomal protein S26, pseudogene 1 Neighboring gene predicted gene, 39241 Neighboring gene WW domain containing E3 ubiquitin protein ligase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC118441, MGC144649, MGC144650

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within maturation of SSU-rRNA ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    acts_upstream_of_or_within ribosomal small subunit biogenesis ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    acts_upstream_of_or_within visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in nucleolus ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    located_in nucleus ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    part_of preribosome, small subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    RNA-binding protein NOB1
    Names
    PSMD8 binding protein 1
    nin one binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026277.3NP_080553.1  RNA-binding protein NOB1

      See identical proteins and their annotated locations for NP_080553.1

      Status: VALIDATED

      Source sequence(s)
      AC158364
      Consensus CDS
      CCDS22649.1
      UniProtKB/Swiss-Prot
      Q7TPR3, Q8BW10, Q9CRD7
      UniProtKB/TrEMBL
      Q148S3
      Related
      ENSMUSP00000003946.9, ENSMUST00000003946.9
      Conserved Domains (4) summary
      cd09876
      Location:7115
      PIN_Nob1; PIN domain of eukaryotic ribosome assembly factor Nob1 and archaeal UPF0129 protein Ta0041-like homologs
      COG1439
      Location:8292
      Nob1; rRNA maturation endonuclease Nob1 [Translation, ribosomal structure and biogenesis]
      pfam15017
      Location:135211
      AF1Q; Drug resistance and apoptosis regulator
      pfam08772
      Location:251323
      NOB1_Zn_bind; Nin one binding (NOB1) Zn-ribbon like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      108139121..108151670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)