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    Rnf41 ring finger protein 41 [ Mus musculus (house mouse) ]

    Gene ID: 67588, updated on 16-Oct-2021

    Summary

    Official Symbol
    Rnf41provided by MGI
    Official Full Name
    ring finger protein 41provided by MGI
    Primary source
    MGI:MGI:1914838
    See related
    Ensembl:ENSMUSG00000025373
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FLRF; Nrdp1; D10Ertd722e; 2210404G21Rik; 4930511A05Rik; 4933415P08Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 22.7), CNS E18 (RPKM 16.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rnf41 in Genome Data Viewer
    Location:
    10 D3; 10 76.55 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128247485..128277310)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128411616..128441441)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127848672..127878497)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (metal ion transporter), member 5 Neighboring gene nucleic acid binding protein 2 Neighboring gene predicted gene, 26347 Neighboring gene nuclear encoded tRNA serine 2 (anticodon CGA) Neighboring gene microRNA 8105

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables erythropoietin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-3 receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of mitophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
     
    acts_upstream_of_or_within regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of establishment of cell polarity IDA
    Inferred from Direct Assay
    more info
     
    acts_upstream_of_or_within regulation of gene expression IDA
    Inferred from Direct Assay
    more info
     
    acts_upstream_of_or_within regulation of lymphocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum tubular network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase NRDP1
    Names
    RING-type E3 ubiquitin transferase NRDP1
    NP_001157709.1
    NP_080535.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164237.1NP_001157709.1  E3 ubiquitin-protein ligase NRDP1

      See identical proteins and their annotated locations for NP_001157709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript which encodes a functional protein.
      Source sequence(s)
      AK028551, AK045760, BC049078
      Consensus CDS
      CCDS24277.1
      UniProtKB/Swiss-Prot
      Q8BH75
      Related
      ENSMUSP00000100869.4, ENSMUST00000096386.13
      Conserved Domains (2) summary
      cd16634
      Location:1557
      mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins
      pfam08941
      Location:137315
      USP8_interact; USP8 interacting
    2. NM_026259.3NP_080535.2  E3 ubiquitin-protein ligase NRDP1

      See identical proteins and their annotated locations for NP_080535.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK045760, BC049078
      Consensus CDS
      CCDS24277.1
      UniProtKB/Swiss-Prot
      Q8BH75
      Related
      ENSMUSP00000132751.2, ENSMUST00000171342.3
      Conserved Domains (2) summary
      cd16634
      Location:1557
      mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins
      pfam08941
      Location:137315
      USP8_interact; USP8 interacting

    RNA

    1. NR_104288.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK028551, AK045760, BC049078
    2. NR_104289.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK028551, AK031657, AK045760, BC049078
    3. NR_104290.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an alternate internal exon in the 5' region and lacks an internal segment in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK016825, AK028551, AK045760, BC049078

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128247485..128277310
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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