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    Tbc1d23 TBC1 domain family, member 23 [ Mus musculus (house mouse) ]

    Gene ID: 67581, updated on 2-Oct-2018

    Summary

    Official Symbol
    Tbc1d23provided by MGI
    Official Full Name
    TBC1 domain family, member 23provided by MGI
    Primary source
    MGI:MGI:1914831
    See related
    Ensembl:ENSMUSG00000022749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    W51689; AU015720; AU043671; AU043778; 4930451A13Rik; D030022P07Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 9.9), limb E14.5 (RPKM 9.6) and 27 other tissues See more
    Orthologs

    Genomic context

    See Tbc1d23 in Genome Data Viewer
    Location:
    16; 16 C1.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (57168858..57231533, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (57168975..57231579, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 70A Neighboring gene nitrilase family, member 2 Neighboring gene transmembrane protein 30C Neighboring gene predicted gene, 26800 Neighboring gene RIKEN cDNA 4921517D16 gene Neighboring gene cms small ribosomal subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    brain development ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-6 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle tethering to Golgi ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with WASH complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with WASH complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TBC1 domain family member 23

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358433.1NP_001345362.1  TBC1 domain family member 23 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154625
      Conserved Domains (2) summary
      pfam00566
      Location:48246
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam00581
      Location:334384
      Rhodanese; Rhodanese-like domain
    2. NM_001358434.1NP_001345363.1  TBC1 domain family member 23 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC154625
      Conserved Domains (1) summary
      pfam00581
      Location:101151
      Rhodanese; Rhodanese-like domain
    3. NM_026254.2NP_080530.2  TBC1 domain family member 23 isoform 2

      See identical proteins and their annotated locations for NP_080530.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      BC031706
      Consensus CDS
      CCDS28228.1
      UniProtKB/Swiss-Prot
      Q8K0F1
      Related
      ENSMUSP00000023431.6, ENSMUST00000023431.7
      Conserved Domains (2) summary
      pfam00566
      Location:79246
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl00125
      Location:328439
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      57168858..57231533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522484.3XP_006522547.1  TBC1 domain family member 23 isoform X1

      Related
      ENSMUSP00000154535.1, ENSMUST00000226586.1
      Conserved Domains (2) summary
      pfam00566
      Location:48246
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam00581
      Location:334384
      Rhodanese; Rhodanese-like domain
    2. XM_006522485.1XP_006522548.1  TBC1 domain family member 23 isoform X2

      Conserved Domains (2) summary
      cl00125
      Location:176287
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
      cl02495
      Location:494
      RabGAP-TBC; Rab-GTPase-TBC domain
    3. XM_017317122.1XP_017172611.1  TBC1 domain family member 23 isoform X4

      Conserved Domains (1) summary
      cl00125
      Location:91202
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
    4. XM_006522486.2XP_006522549.1  TBC1 domain family member 23 isoform X3

      Conserved Domains (1) summary
      pfam00581
      Location:101151
      Rhodanese; Rhodanese-like domain
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