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    Tbc1d23 TBC1 domain family, member 23 [ Mus musculus (house mouse) ]

    Gene ID: 67581, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tbc1d23provided by MGI
    Official Full Name
    TBC1 domain family, member 23provided by MGI
    Primary source
    MGI:MGI:1914831
    See related
    Ensembl:ENSMUSG00000022749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    W51689; AU015720; AU043671; AU043778; 4930451A13Rik; D030022P07Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 9.9), limb E14.5 (RPKM 9.6) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tbc1d23 in Genome Data Viewer
    Location:
    16; 16 C1.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (56989225..57051891, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (57168862..57231528, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (57168975..57231579, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 70A Neighboring gene predicted gene, 16892 Neighboring gene nitrilase family, member 2 Neighboring gene transmembrane protein 30C Neighboring gene predicted gene, 26800 Neighboring gene RIKEN cDNA 4921517D16 gene Neighboring gene cms small ribosomal subunit 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of WASH complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of WASH complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    TBC1 domain family member 23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358433.1NP_001345362.1  TBC1 domain family member 23 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC154625
      Consensus CDS
      CCDS88947.1
      Related
      ENSMUSP00000154535.2, ENSMUST00000226586.2
      Conserved Domains (2) summary
      pfam00566
      Location:48246
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam00581
      Location:334384
      Rhodanese; Rhodanese-like domain
    2. NM_001358434.1NP_001345363.1  TBC1 domain family member 23 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC154625
      Conserved Domains (2) summary
      pfam00581
      Location:101151
      Rhodanese; Rhodanese-like domain
      cd20788
      Location:346460
      TBC1D23_C-like; C-terminal domain of TBC1 domain family member 23, and similar proteins
    3. NM_026254.2NP_080530.2  TBC1 domain family member 23 isoform 2

      See identical proteins and their annotated locations for NP_080530.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      BC031706
      Consensus CDS
      CCDS28228.1
      UniProtKB/Swiss-Prot
      Q8K0F1
      Related
      ENSMUSP00000023431.7, ENSMUST00000023431.8
      Conserved Domains (2) summary
      pfam00566
      Location:79246
      RabGAP-TBC; Rab-GTPase-TBC domain
      cl00125
      Location:328439
      RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      56989225..57051891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160099.1XP_036015992.1  TBC1 domain family member 23 isoform X5

      Conserved Domains (2) summary
      pfam00581
      Location:101151
      Rhodanese; Rhodanese-like domain
      cd20788
      Location:331445
      TBC1D23_C-like; C-terminal domain of TBC1 domain family member 23, and similar proteins
    2. XM_030249251.1XP_030105111.1  TBC1 domain family member 23 isoform X2

      Conserved Domains (2) summary
      pfam00581
      Location:182229
      Rhodanese; Rhodanese-like domain
      cl02495
      Location:494
      RabGAP-TBC; Rab-GTPase-TBC domain
    3. XM_036160100.1XP_036015993.1  TBC1 domain family member 23 isoform X5

      Conserved Domains (2) summary
      pfam00581
      Location:101151
      Rhodanese; Rhodanese-like domain
      cd20788
      Location:331445
      TBC1D23_C-like; C-terminal domain of TBC1 domain family member 23, and similar proteins
    4. XM_030249252.2XP_030105112.1  TBC1 domain family member 23 isoform X4

      Conserved Domains (2) summary
      pfam00581
      Location:97147
      Rhodanese; Rhodanese-like domain
      cd20788
      Location:342456
      TBC1D23_C-like; C-terminal domain of TBC1 domain family member 23, and similar proteins
    5. XM_030249253.2XP_030105113.1  TBC1 domain family member 23 isoform X4

      Conserved Domains (2) summary
      pfam00581
      Location:97147
      Rhodanese; Rhodanese-like domain
      cd20788
      Location:342456
      TBC1D23_C-like; C-terminal domain of TBC1 domain family member 23, and similar proteins
    6. XM_006522485.3XP_006522548.1  TBC1 domain family member 23 isoform X1

      Conserved Domains (2) summary
      pfam00581
      Location:182229
      Rhodanese; Rhodanese-like domain
      cl02495
      Location:494
      RabGAP-TBC; Rab-GTPase-TBC domain
    7. XM_036160098.1XP_036015991.1  TBC1 domain family member 23 isoform X4

      Conserved Domains (2) summary
      pfam00581
      Location:97147
      Rhodanese; Rhodanese-like domain
      cd20788
      Location:342456
      TBC1D23_C-like; C-terminal domain of TBC1 domain family member 23, and similar proteins
    8. XM_030249250.2XP_030105110.1  TBC1 domain family member 23 isoform X1

      Conserved Domains (2) summary
      pfam00581
      Location:182229
      Rhodanese; Rhodanese-like domain
      cl02495
      Location:494
      RabGAP-TBC; Rab-GTPase-TBC domain
    9. XM_036160097.1XP_036015990.1  TBC1 domain family member 23 isoform X3

      Conserved Domains (2) summary
      pfam00581
      Location:101151
      Rhodanese; Rhodanese-like domain
      cd20788
      Location:346460
      TBC1D23_C-like; C-terminal domain of TBC1 domain family member 23, and similar proteins
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