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    Ccar1 cell division cycle and apoptosis regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 67500, updated on 24-Apr-2022

    Summary

    Official Symbol
    Ccar1provided by MGI
    Official Full Name
    cell division cycle and apoptosis regulator 1provided by MGI
    Primary source
    MGI:MGI:1914750
    See related
    Ensembl:ENSMUSG00000020074 AllianceGenome:MGI:1914750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Carp1; 2610511G16Rik; 9430036H15Rik
    Summary
    Enables transcription coactivator activity. Predicted to be involved in positive regulation of cell migration; positive regulation of cell population proliferation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within positive regulation of apoptotic process. Predicted to be located in nuclear envelope lumen. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human CCAR1 (cell division cycle and apoptosis regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 29.0), CNS E14 (RPKM 18.9) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ccar1 in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62579707..62628147, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62743928..62792368, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (62206676..62255116, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene storkhead box 1 Neighboring gene microRNA 7215 Neighboring gene NHP2 ribonucleoprotein pseudogene Neighboring gene small nucleolar RNA, C/D box 98 Neighboring gene tet methylcytosine dioxygenase 1 Neighboring gene predicted gene, 51805 Neighboring gene CRISPRi-validated Tet1 enhancer cluster Neighboring gene predicted gene, 26479

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC90759

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear envelope lumen ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    cell division cycle and apoptosis regulator protein 1
    Names
    CARP-1
    cell cycle and apoptosis regulatory protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026201.3NP_080477.1  cell division cycle and apoptosis regulator protein 1

      See identical proteins and their annotated locations for NP_080477.1

      Status: VALIDATED

      Source sequence(s)
      AC122539
      Consensus CDS
      CCDS35922.1
      UniProtKB/Swiss-Prot
      Q8CH18
      Related
      ENSMUSP00000151895.2, ENSMUST00000219527.2
      Conserved Domains (5) summary
      smart00513
      Location:634667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PRK10927
      Location:184303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:10341141
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:479598
      DBC1
      pfam14444
      Location:145201
      S1-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62579707..62628147 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513997.4XP_006514060.1  cell division cycle and apoptosis regulator protein 1 isoform X2

      UniProtKB/Swiss-Prot
      Q8CH18
      Conserved Domains (4) summary
      PRK10927
      Location:184303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:9721079
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:476601
      DBC1
      pfam14444
      Location:145201
      S1-like
    2. XM_036155963.1XP_036011856.1  cell division cycle and apoptosis regulator protein 1 isoform X2

      Conserved Domains (4) summary
      PRK10927
      Location:184303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:9721079
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:476601
      DBC1
      pfam14444
      Location:145201
      S1-like
    3. XM_006513996.4XP_006514059.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006514059.1

      UniProtKB/Swiss-Prot
      Q8CH18
      Conserved Domains (5) summary
      smart00513
      Location:634667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PRK10927
      Location:184303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:10341141
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:479598
      DBC1
      pfam14444
      Location:145201
      S1-like
    4. XM_011243537.4XP_011241839.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011241839.1

      UniProtKB/Swiss-Prot
      Q8CH18
      Related
      ENSMUSP00000020268.6, ENSMUST00000020268.7
      Conserved Domains (5) summary
      smart00513
      Location:634667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PRK10927
      Location:184303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:10341141
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:479598
      DBC1
      pfam14444
      Location:145201
      S1-like
    5. XM_006513994.5XP_006514057.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006514057.1

      UniProtKB/Swiss-Prot
      Q8CH18
      Conserved Domains (5) summary
      smart00513
      Location:634667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PRK10927
      Location:184303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:10341141
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:479598
      DBC1
      pfam14444
      Location:145201
      S1-like
    6. XM_006513995.4XP_006514058.1  cell division cycle and apoptosis regulator protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006514058.1

      UniProtKB/Swiss-Prot
      Q8CH18
      Conserved Domains (5) summary
      smart00513
      Location:634667
      SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
      PRK10927
      Location:184303
      PRK10927; cell division protein FtsN
      TIGR04523
      Location:10341141
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam14443
      Location:479598
      DBC1
      pfam14444
      Location:145201
      S1-like