Format

Send to:

Choose Destination
    • Showing Current items.

    Ap4b1 adaptor-related protein complex AP-4, beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 67489, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ap4b1provided by MGI
    Official Full Name
    adaptor-related protein complex AP-4, beta 1provided by MGI
    Primary source
    MGI:MGI:1337130
    See related
    Ensembl:ENSMUSG00000032952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ap4b4; AV004952; 1810038H16Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 13.7), limb E14.5 (RPKM 8.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ap4b1 in Genome Data Viewer
    Location:
    3; 3 F2.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (103809517..103822025)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (103613440..103625948)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene homeodomain interacting protein kinase 1 Neighboring gene predicted gene 15886 Neighboring gene DNA cross-link repair 1B Neighboring gene predicted gene 15471 Neighboring gene BCLl2-like 15 Neighboring gene protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    AP-4 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    AP-4 complex subunit beta-1
    Names
    AP-4 adapter complex subunit beta
    AP-4 adaptor complex subunit beta
    AP-4 beta-4
    adapter-related protein complex 4 subunit beta-1
    adaptor-related protein complex 4 subunit beta-1
    beta subunit of AP-4
    beta4-adaptin

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163552.1NP_001157024.1  AP-4 complex subunit beta-1 isoform a

      See identical proteins and their annotated locations for NP_001157024.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK007733, BC056200, BE630857, BY129343
      Consensus CDS
      CCDS17696.1
      UniProtKB/Swiss-Prot
      Q9WV76
      UniProtKB/TrEMBL
      Q7TND3, Q9D8S2
      Related
      ENSMUSP00000075904.1, ENSMUST00000076599.7
      Conserved Domains (4) summary
      smart01020
      Location:619731
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:9525
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:98235
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:86113
      HEAT; HEAT repeat [structural motif]
    2. NM_001163553.1NP_001157025.1  AP-4 complex subunit beta-1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK007733, BC056200, BE630857, BY129343
      Consensus CDS
      CCDS51026.1
      UniProtKB/TrEMBL
      B0V3P4, Q7TND3, Q9D8S2
      Related
      ENSMUSP00000102436.1, ENSMUST00000106823.7
      Conserved Domains (4) summary
      smart01020
      Location:591703
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:9497
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:98235
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:86113
      HEAT; HEAT repeat [structural motif]
    3. NM_026193.2NP_080469.2  AP-4 complex subunit beta-1 isoform a

      See identical proteins and their annotated locations for NP_080469.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK007733, BC056200, BE630857, BY129343
      Consensus CDS
      CCDS17696.1
      UniProtKB/Swiss-Prot
      Q9WV76
      UniProtKB/TrEMBL
      Q7TND3, Q9D8S2
      Related
      ENSMUSP00000044262.2, ENSMUST00000047285.6
      Conserved Domains (4) summary
      smart01020
      Location:619731
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:9525
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:98235
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:86113
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      103809517..103822025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501932.1XP_006501995.1  AP-4 complex subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_006501995.1

      Conserved Domains (4) summary
      smart01020
      Location:603715
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:24509
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:82219
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:7097
      HEAT; HEAT repeat [structural motif]
    2. XM_006501933.3XP_006501996.1  AP-4 complex subunit beta-1 isoform X1

      See identical proteins and their annotated locations for XP_006501996.1

      Conserved Domains (4) summary
      smart01020
      Location:603715
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:24509
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:82219
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:7097
      HEAT; HEAT repeat [structural motif]

    RNA

    1. XR_375568.3 RNA Sequence

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_166287.2 Reference GRCm38.p4 NOD/MrkTac

      Range
      219162..231670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center