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    Ap4b1 adaptor-related protein complex AP-4, beta 1 [ Mus musculus (house mouse) ]

    Gene ID: 67489, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ap4b1provided by MGI
    Official Full Name
    adaptor-related protein complex AP-4, beta 1provided by MGI
    Primary source
    MGI:MGI:1337130
    See related
    Ensembl:ENSMUSG00000032952
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ap4b4; AV004952; 1810038H16Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 13.7), limb E14.5 (RPKM 8.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ap4b1 in Genome Data Viewer
    Location:
    3; 3 F2.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (103716375..103729341)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (103809511..103822025)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (103613440..103625948)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene homeodomain interacting protein kinase 1 Neighboring gene predicted gene 15886 Neighboring gene DNA cross-link repair 1B Neighboring gene predicted gene 15471 Neighboring gene BCLl2-like 15 Neighboring gene protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AP-4 adaptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    located_in trans-Golgi network TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    AP-4 complex subunit beta-1
    Names
    AP-4 adapter complex subunit beta
    AP-4 adaptor complex subunit beta
    AP-4 beta-4
    adapter-related protein complex 4 subunit beta-1
    adaptor-related protein complex 4 subunit beta-1
    beta subunit of AP-4
    beta4-adaptin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163552.1NP_001157024.1  AP-4 complex subunit beta-1 isoform a

      See identical proteins and their annotated locations for NP_001157024.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK007733, BC056200, BE630857, BY129343
      Consensus CDS
      CCDS17696.1
      UniProtKB/Swiss-Prot
      Q9WV76
      UniProtKB/TrEMBL
      Q7TND3, Q9D8S2
      Related
      ENSMUSP00000075904.2, ENSMUST00000076599.8
      Conserved Domains (3) summary
      sd00044
      Location:86113
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:9525
      Adaptin_N; Adaptin N terminal region
      pfam09066
      Location:620729
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    2. NM_001163553.1NP_001157025.1  AP-4 complex subunit beta-1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AK007733, BC056200, BE630857, BY129343
      Consensus CDS
      CCDS51026.1
      UniProtKB/TrEMBL
      B0V3P4, Q7TND3, Q9D8S2
      Related
      ENSMUSP00000102436.2, ENSMUST00000106823.8
      Conserved Domains (4) summary
      smart01020
      Location:591703
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      pfam01602
      Location:9497
      Adaptin_N; Adaptin N terminal region
      pfam12717
      Location:98235
      Cnd1; non-SMC mitotic condensation complex subunit 1
      sd00044
      Location:86113
      HEAT; HEAT repeat [structural motif]
    3. NM_026193.2NP_080469.2  AP-4 complex subunit beta-1 isoform a

      See identical proteins and their annotated locations for NP_080469.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AK007733, BC056200, BE630857, BY129343
      Consensus CDS
      CCDS17696.1
      UniProtKB/Swiss-Prot
      Q9WV76
      UniProtKB/TrEMBL
      Q7TND3, Q9D8S2
      Related
      ENSMUSP00000044262.3, ENSMUST00000047285.7
      Conserved Domains (3) summary
      sd00044
      Location:86113
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:9525
      Adaptin_N; Adaptin N terminal region
      pfam09066
      Location:620729
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      103716375..103729341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163245.1XP_036019138.1  AP-4 complex subunit beta-1 isoform X1

      Conserved Domains (3) summary
      sd00044
      Location:86113
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:9525
      Adaptin_N; Adaptin N terminal region
      pfam09066
      Location:620729
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    2. XM_036163246.1XP_036019139.1  AP-4 complex subunit beta-1 isoform X1

      Conserved Domains (3) summary
      sd00044
      Location:86113
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:9525
      Adaptin_N; Adaptin N terminal region
      pfam09066
      Location:620729
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    3. XM_006501932.1XP_006501995.1  AP-4 complex subunit beta-1 isoform X2

      See identical proteins and their annotated locations for XP_006501995.1

      Conserved Domains (3) summary
      smart01020
      Location:603715
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:7097
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:24509
      Adaptin_N; Adaptin N terminal region
    4. XM_006501933.4XP_006501996.1  AP-4 complex subunit beta-1 isoform X2

      See identical proteins and their annotated locations for XP_006501996.1

      Conserved Domains (3) summary
      smart01020
      Location:603715
      B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
      sd00044
      Location:7097
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:24509
      Adaptin_N; Adaptin N terminal region

    RNA

    1. XR_375568.5 RNA Sequence

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