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    Cwc25 CWC25 spliceosome-associated protein [ Mus musculus (house mouse) ]

    Gene ID: 67480, updated on 23-Nov-2023


    Official Symbol
    Cwc25provided by MGI
    Official Full Name
    CWC25 spliceosome-associated proteinprovided by MGI
    Primary source
    See related
    Ensembl:ENSMUSG00000018541 AllianceGenome:MGI:1914730
    Gene type
    protein coding
    RefSeq status
    Mus musculus
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc49; 1300013D05Rik
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of U2-type catalytic step 1 spliceosome. Is expressed in dermis and epidermis. Orthologous to human CWC25 (CWC25 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Ubiquitous expression in CNS E11.5 (RPKM 7.3), limb E14.5 (RPKM 5.5) and 28 other tissues See more
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    Genomic context

    See Cwc25 in Genome Data Viewer
    11 D; 11 61.09 cM
    Exon count:
    Annotation release Status Assembly Chr Location
    RS_2023_04 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97636296..97657439, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97745470..97766613, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, beta Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97606458-97606567 Neighboring gene microRNA 8102 Neighboring gene ATP synthase, H+ transporting, mitochondrial FO complex, subunit G2, pseudogene Neighboring gene nuclear encoded tRNA cysteine 18 (anticodon GCA)

    Genomic regions, transcripts, and products


    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a



    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information


    Clone Names

    • MGC90568

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info

    General protein information

    Preferred Names
    pre-mRNA-splicing factor CWC25 homolog
    CWC25 spliceosome-associated protein homolog
    coiled-coil domain containing 49
    coiled-coil domain-containing protein 49
    spliceosome-associated protein homolog CWC25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026186.4NP_080462.2  pre-mRNA-splicing factor CWC25 homolog

      See identical proteins and their annotated locations for NP_080462.2

      Status: VALIDATED

      Source sequence(s)
      AK004983, BC053447, BY307671, BY488530
      Consensus CDS
      A2A6F4, Q6AXH2, Q7TSF8, Q9DBF7
      ENSMUSP00000018685.3, ENSMUST00000018685.9
      Conserved Domains (2) summary
      Cir_N; N-terminal domain of CBF1 interacting co-repressor CIR
      CWC25; Pre-mRNA splicing factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J


    1. NC_000077.7 Reference GRCm39 C57BL/6J

      97636296..97657439 complement
      GenBank, FASTA, Sequence Viewer (Graphics)