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    Mtfr1 mitochondrial fission regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 67472, updated on 27-Nov-2024

    Summary

    Official Symbol
    Mtfr1provided by MGI
    Official Full Name
    mitochondrial fission regulator 1provided by MGI
    Primary source
    MGI:MGI:1914722
    See related
    Ensembl:ENSMUSG00000027601 AllianceGenome:MGI:1914722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chppr; Fam54a2; 1300002C08Rik; 1700080D04Rik; 2810026O10Rik; 4930579E05Rik
    Summary
    Involved in aerobic respiration. Located in mitochondrion. Is expressed in brain; embryo; and testis. Orthologous to human MTFR1 (mitochondrial fission regulator 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 71.8), liver E14 (RPKM 19.6) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mtfr1 in Genome Data Viewer
    Location:
    3 A2; 3 5.36 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (19241481..19274981)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (19187315..19220817)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07084 Neighboring gene predicted gene, 30341 Neighboring gene STARR-seq mESC enhancer starr_07085 Neighboring gene STARR-seq mESC enhancer starr_07087 Neighboring gene STARR-positive B cell enhancer ABC_E334 Neighboring gene STARR-positive B cell enhancer ABC_E3427 Neighboring gene armadillo repeat containing 1 Neighboring gene STARR-seq mESC enhancer starr_07090 Neighboring gene STARR-seq mESC enhancer starr_07091 Neighboring gene phosphodiesterase 7A Neighboring gene RIKEN cDNA 3110037C07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:19250042-19250343 Neighboring gene predicted gene, 52602

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mitochondrial fission regulator 1
    Names
    chondrocyte protein with a poly-proline region

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253390.3NP_001240319.1  mitochondrial fission regulator 1

      See identical proteins and their annotated locations for NP_001240319.1

      Status: VALIDATED

      Source sequence(s)
      AC127283
      Consensus CDS
      CCDS17256.1
      UniProtKB/Swiss-Prot
      Q99MB2, Q9CQZ4
      UniProtKB/TrEMBL
      Q3TTQ5, Q8CGA8
      Related
      ENSMUSP00000112752.2, ENSMUST00000119865.8
      Conserved Domains (1) summary
      pfam05308
      Location:24249
      Mito_fiss_reg; Mitochondrial fission regulator
    2. NM_001253391.3NP_001240320.1  mitochondrial fission regulator 1

      See identical proteins and their annotated locations for NP_001240320.1

      Status: VALIDATED

      Source sequence(s)
      AC127283
      Consensus CDS
      CCDS17256.1
      UniProtKB/Swiss-Prot
      Q99MB2, Q9CQZ4
      UniProtKB/TrEMBL
      Q3TTQ5, Q8CGA8
      Related
      ENSMUSP00000112824.2, ENSMUST00000117529.8
      Conserved Domains (1) summary
      pfam05308
      Location:24249
      Mito_fiss_reg; Mitochondrial fission regulator
    3. NM_001356295.2NP_001343224.1  mitochondrial fission regulator 1

      Status: VALIDATED

      Source sequence(s)
      AC127283
      Consensus CDS
      CCDS17256.1
      UniProtKB/Swiss-Prot
      Q99MB2, Q9CQZ4
      UniProtKB/TrEMBL
      Q3TTQ5, Q8CGA8
      Conserved Domains (1) summary
      pfam05308
      Location:24249
      Mito_fiss_reg; Mitochondrial fission regulator
    4. NM_001428962.1NP_001415891.1  mitochondrial fission regulator 1

      Status: VALIDATED

      Source sequence(s)
      AC127283
      UniProtKB/Swiss-Prot
      Q99MB2, Q9CQZ4
      UniProtKB/TrEMBL
      Q3TTQ5
    5. NM_026182.7NP_080458.1  mitochondrial fission regulator 1

      See identical proteins and their annotated locations for NP_080458.1

      Status: VALIDATED

      Source sequence(s)
      AC127283
      Consensus CDS
      CCDS17256.1
      UniProtKB/Swiss-Prot
      Q99MB2, Q9CQZ4
      UniProtKB/TrEMBL
      Q3TTQ5, Q8CGA8
      Related
      ENSMUSP00000119724.2, ENSMUST00000130645.8
      Conserved Domains (1) summary
      pfam05308
      Location:24249
      Mito_fiss_reg; Mitochondrial fission regulator

    RNA

    1. NR_045575.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC127283

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      19241481..19274981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249708.4XP_011248010.1  mitochondrial fission regulator 1 isoform X1

      Conserved Domains (1) summary
      pfam05308
      Location:24249
      Mito_fiss_reg; Mitochondrial fission regulator
    2. XM_036163244.1XP_036019137.1  mitochondrial fission regulator 1 isoform X2

      Conserved Domains (1) summary
      pfam05308
      Location:24249
      Mito_fiss_reg; Mitochondrial fission regulator