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    Abhd5 abhydrolase domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 67469, updated on 23-Jun-2021

    Summary

    Official Symbol
    Abhd5provided by MGI
    Official Full Name
    abhydrolase domain containing 5provided by MGI
    Primary source
    MGI:MGI:1914719
    See related
    Ensembl:ENSMUSG00000032540
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IEC; NCI; CGI-5; IECN5; NCIE2; CGI-58; 1300003D03Rik; 2010002J10Rik
    Expression
    Broad expression in testis adult (RPKM 60.2), liver E18 (RPKM 34.9) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Abhd5 in Genome Data Viewer
    Location:
    9; 9 F4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (122180681..122210589)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (122351616..122381524)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (122260734..122290641)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35289 Neighboring gene predicted gene, 35398 Neighboring gene RIKEN cDNA A730085K08 gene Neighboring gene predicted gene, 35454

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables lysophosphatidic acid acyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables triglyceride lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of sequestering of triglyceride IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of sequestering of triglyceride IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of sequestering of triglyceride ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phosphatidic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of lipoprotein lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of triglyceride catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of triglyceride catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of triglyceride catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lipid droplet TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    1-acylglycerol-3-phosphate O-acyltransferase ABHD5
    Names
    abhydrolase domain-containing protein 5
    lipid droplet-binding protein CGI-58
    NP_001346136.1
    NP_080455.1
    XP_030100386.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359207.1NP_001346136.1  1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC108846
      Consensus CDS
      CCDS90688.1
      Related
      ENSMUSP00000107123.4, ENSMUST00000111497.5
      Conserved Domains (1) summary
      PLN02894
      Location:19194
      PLN02894; hydrolase, alpha/beta fold family protein
    2. NM_026179.2NP_080455.1  1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 1

      See identical proteins and their annotated locations for NP_080455.1

      Status: VALIDATED

      Source sequence(s)
      AK004873, AK050377, CN840045
      Consensus CDS
      CCDS23646.1
      UniProtKB/Swiss-Prot
      Q9DBL9
      Related
      ENSMUSP00000122274.2, ENSMUST00000156520.8
      Conserved Domains (1) summary
      PLN02894
      Location:3347
      PLN02894; hydrolase, alpha/beta fold family protein

    RNA

    1. NR_152865.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108846

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      122180681..122210589
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244526.2XP_030100386.1  1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform X1

      Conserved Domains (1) summary
      PLN02894
      Location:53304
      PLN02894; hydrolase, alpha/beta fold family protein
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