U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Frmd8 FERM domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 67457, updated on 18-Sep-2024

    Summary

    Official Symbol
    Frmd8provided by MGI
    Official Full Name
    FERM domain containing 8provided by MGI
    Primary source
    MGI:MGI:1914707
    See related
    Ensembl:ENSMUSG00000024816 AllianceGenome:MGI:1914707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    iTAP; 1200004M23Rik; 2310035N23Rik; 4931429L16Rik
    Summary
    Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Predicted to be located in centriolar satellite; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including forelimb bud; otic capsule; and skeleton. Orthologous to several human genes including FRMD8 (FERM domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 47.8), small intestine adult (RPKM 26.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Frmd8 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5901002..5925297, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5850974..5875269, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45401 Neighboring gene Malat1-associated small cytoplasmic RNA Neighboring gene metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) Neighboring gene STARR-positive B cell enhancer ABC_E5679 Neighboring gene STARR-seq mESC enhancer starr_45402 Neighboring gene nuclear paraspeckle assembly transcript 1 (non-protein coding) Neighboring gene STARR-seq mESC enhancer starr_45410 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5844330-5844513 Neighboring gene STARR-seq mESC enhancer starr_45411 Neighboring gene FERM domain containing 8, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:5878208-5878317 Neighboring gene solute carrier family 25, member 45 Neighboring gene STARR-positive B cell enhancer ABC_E1522 Neighboring gene tigger transposable element derived 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    FERM domain-containing protein 8
    Names
    iRhom tail-associated protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026169.4NP_080445.1  FERM domain-containing protein 8

      See identical proteins and their annotated locations for NP_080445.1

      Status: VALIDATED

      Source sequence(s)
      AK083902
      Consensus CDS
      CCDS29481.1
      UniProtKB/Swiss-Prot
      Q3UFK8, Q8C7U3, Q8C7U5, Q99KB3, Q9CSY6, Q9DC30
      Related
      ENSMUSP00000025728.7, ENSMUST00000025728.13
      Conserved Domains (1) summary
      pfam00373
      Location:137273
      FERM_M; FERM central domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5901002..5925297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531829.4XP_006531892.1  FERM domain-containing protein 8 isoform X2

      Conserved Domains (1) summary
      pfam00373
      Location:137273
      FERM_M; FERM central domain
    2. XM_006531828.3XP_006531891.1  FERM domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006531891.1

      UniProtKB/Swiss-Prot
      Q3UFK8, Q8C7U3, Q8C7U5, Q99KB3, Q9CSY6, Q9DC30
      Conserved Domains (1) summary
      pfam00373
      Location:137273
      FERM_M; FERM central domain