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    Map1lc3b microtubule-associated protein 1 light chain 3 beta [ Mus musculus (house mouse) ]

    Gene ID: 67443, updated on 24-Aug-2021

    Summary

    Official Symbol
    Map1lc3bprovided by MGI
    Official Full Name
    microtubule-associated protein 1 light chain 3 betaprovided by MGI
    Primary source
    MGI:MGI:1914693
    See related
    Ensembl:ENSMUSG00000031812
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Atg; LC3; Atg8; LC3b; Map1; Map1lc3; MAP1A/MAP1B; 1010001C15Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 80.9), adrenal adult (RPKM 77.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Map1lc3b in Genome Data Viewer
    Location:
    8; 8 E1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (122317177..122325499)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121590438..121598760)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (124114368..124121947)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA methionine 17 (anticodon CAT) Neighboring gene predicted gene, 17786 Neighboring gene zinc finger, CCHC domain containing 14 Neighboring gene VISTA enhancer mm323 Neighboring gene predicted gene, 46065

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC118046

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ceramide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mucus secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in autolysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in autophagosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    part_of microtubule associated complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    microtubule-associated proteins 1A/1B light chain 3B
    Names
    MAP1 light chain 3-like protein 2
    MAP1A/MAP1B light chain 3 B
    autophagy-related protein LC3 B
    autophagy-related ubiquitin-like modifier LC3 B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364358.1NP_001351287.1  microtubule-associated proteins 1A/1B light chain 3B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC182458
      Consensus CDS
      CCDS90470.1
      Related
      ENSMUSP00000137754.2, ENSMUST00000181948.2
      Conserved Domains (1) summary
      cd01611
      Location:7155
      GABARAP; Ubiquitin domain of GABA-receptor-associated protein
    2. NM_026160.5NP_080436.1  microtubule-associated proteins 1A/1B light chain 3B isoform 1

      See identical proteins and their annotated locations for NP_080436.1

      Status: VALIDATED

      Source sequence(s)
      AC182458
      Consensus CDS
      CCDS22726.1
      UniProtKB/Swiss-Prot
      Q9CQV6
      Related
      ENSMUSP00000034270.10, ENSMUST00000034270.17
      Conserved Domains (1) summary
      cd17235
      Location:5119
      Ubl_ATG8_MAP1LC3B; ubiquitin-like (Ubl) domain found in microtubule associate protein 1 light chain 3B (MAP1LC3B)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      122317177..122325499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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