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    Mtpap mitochondrial poly(A) polymerase [ Mus musculus (house mouse) ]

    Gene ID: 67440, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mtpapprovided by MGI
    Official Full Name
    mitochondrial poly(A) polymeraseprovided by MGI
    Primary source
    MGI:MGI:1914690
    See related
    Ensembl:ENSMUSG00000024234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pa; Tent; Papd1; Tent6; AW551379; 0610027A18Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 4.5), whole brain E14.5 (RPKM 4.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mtpap in Genome Data Viewer
    Location:
    18; 18 A1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (4375573..4399888)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (4375589..4399888)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (4375590..4397328)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 8 Neighboring gene RIKEN cDNA 4833419F23 gene Neighboring gene predicted gene, 52359 Neighboring gene protein arginine N-methyltransferase 8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables UTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables polynucleotide adenylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in histone mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA polyadenylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    poly(A) RNA polymerase, mitochondrial
    Names
    PAP associated domain containing 1
    PAP-associated domain-containing protein 1
    polynucleotide adenylyltransferase
    NP_001347937.1
    NP_001347938.1
    NP_080433.1
    XP_006526247.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361008.2NP_001347937.1  poly(A) RNA polymerase, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC138768, AEKQ02123947
      Conserved Domains (2) summary
      cd05402
      Location:2899
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:57248
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    2. NM_001361009.2NP_001347938.1  poly(A) RNA polymerase, mitochondrial isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC138768, AEKQ02123947
      Conserved Domains (2) summary
      cd05402
      Location:2899
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:57248
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    3. NM_026157.4NP_080433.1  poly(A) RNA polymerase, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_080433.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC138768, AEKQ02123947
      Consensus CDS
      CCDS37718.1
      UniProtKB/Swiss-Prot
      Q9D0D3
      Related
      ENSMUSP00000025077.7, ENSMUST00000025077.7
      Conserved Domains (2) summary
      cd05402
      Location:209347
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:441486
      PAP_assoc; Cid1 family poly A polymerase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      4375573..4399888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006526184.5XP_006526247.1  poly(A) RNA polymerase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006526247.1

      Conserved Domains (2) summary
      cd05402
      Location:2899
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:57248
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    RNA

    1. XR_004939877.1 RNA Sequence

    2. XR_004939879.1 RNA Sequence

    3. XR_004939881.1 RNA Sequence

    4. XR_004939882.1 RNA Sequence

    5. XR_004939880.1 RNA Sequence

    6. XR_004939878.1 RNA Sequence

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