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    Far1 fatty acyl CoA reductase 1 [ Mus musculus (house mouse) ]

    Gene ID: 67420, updated on 12-Aug-2018

    Summary

    Official Symbol
    Far1provided by MGI
    Official Full Name
    fatty acyl CoA reductase 1provided by MGI
    Primary source
    MGI:MGI:1914670
    See related
    Ensembl:ENSMUSG00000030759 Vega:OTTMUSG00000031364
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mlstd2; AI850429; 2600011M19Rik; 2900034E22Rik; 3732409C05Rik
    Expression
    Broad expression in bladder adult (RPKM 22.8), CNS E18 (RPKM 14.0) and 22 other tissues See more
    Orthologs

    Genomic context

    See Far1 in Genome Data Viewer
    Location:
    7; 7 F1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (113513834..113570888)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (120657376..120713972)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene parathyroid hormone Neighboring gene BCL2-associated transcription factor 1 pseudogene Neighboring gene fatty acyl CoA reductase 1, opposite strand Neighboring gene predicted gene, 33828 Neighboring gene predicted gene, 39072

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    fatty-acyl-CoA reductase (alcohol-forming) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    fatty-acyl-CoA reductase (alcohol-forming) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fatty-acyl-CoA reductase (alcohol-forming) activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ether lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    glycerophospholipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    long-chain fatty-acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    wax biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    wax biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    peroxisome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fatty acyl-CoA reductase 1
    Names
    male sterility domain containing 2
    NP_001272760.1
    NP_081655.2
    XP_006508190.1
    XP_006508191.1
    XP_006508192.1
    XP_006508193.1
    XP_006508194.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285831.2NP_001272760.1  fatty acyl-CoA reductase 1 isoform 2

      See identical proteins and their annotated locations for NP_001272760.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate exon in the coding region compared to variant 1. The resulting isoform (2) is the same length and has the same N- and C-termini compared to isoform 1 but differs at an internal segment.
      Source sequence(s)
      AC102841, AC156987, AK033674
      Consensus CDS
      CCDS72024.1
      UniProtKB/Swiss-Prot
      Q922J9
      Related
      ENSMUSP00000064334.8, OTTMUSP00000041165, ENSMUST00000067929.14
      Conserved Domains (3) summary
      cd05236
      Location:11330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam01370
      Location:13300
      Epimerase; NAD dependent epimerase/dehydratase family
      pfam03015
      Location:371447
      Sterile; Male sterility protein
    2. NM_001360668.1NP_001347597.1  fatty acyl-CoA reductase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC102841, AC156987
      Conserved Domains (2) summary
      cd05236
      Location:11330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357447
      Sterile; Male sterility protein
    3. NM_001360669.1NP_001347598.1  fatty acyl-CoA reductase 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC102841, AC156987
      Conserved Domains (2) summary
      cd05236
      Location:11330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357447
      Sterile; Male sterility protein
    4. NM_027379.4NP_081655.2  fatty acyl-CoA reductase 1 isoform 1

      See identical proteins and their annotated locations for NP_081655.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AC102841, AC156987, AK014486
      Consensus CDS
      CCDS40093.1
      UniProtKB/Swiss-Prot
      Q922J9
      Related
      ENSMUSP00000033018.8, OTTMUSP00000041164, ENSMUST00000033018.14
      Conserved Domains (2) summary
      cd05236
      Location:11330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357447
      Sterile; Male sterility protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      113513834..113570888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508128.3XP_006508191.1  fatty acyl-CoA reductase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q922J9
      Related
      ENSMUSP00000128695.1, ENSMUST00000164745.7
      Conserved Domains (2) summary
      cd05236
      Location:11330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357447
      Sterile; Male sterility protein
    2. XM_006508127.3XP_006508190.1  fatty acyl-CoA reductase 1 isoform X1

      UniProtKB/Swiss-Prot
      Q922J9
      Conserved Domains (2) summary
      cd05236
      Location:11330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357447
      Sterile; Male sterility protein
    3. XM_006508130.3XP_006508193.1  fatty acyl-CoA reductase 1 isoform X1

      See identical proteins and their annotated locations for XP_006508193.1

      UniProtKB/Swiss-Prot
      Q922J9
      Conserved Domains (2) summary
      cd05236
      Location:11330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357447
      Sterile; Male sterility protein
    4. XM_006508129.3XP_006508192.1  fatty acyl-CoA reductase 1 isoform X1

      See identical proteins and their annotated locations for XP_006508192.1

      UniProtKB/Swiss-Prot
      Q922J9
      Conserved Domains (2) summary
      cd05236
      Location:11330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357447
      Sterile; Male sterility protein
    5. XM_006508131.3XP_006508194.1  fatty acyl-CoA reductase 1 isoform X1

      See identical proteins and their annotated locations for XP_006508194.1

      UniProtKB/Swiss-Prot
      Q922J9
      Conserved Domains (2) summary
      cd05236
      Location:11330
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      pfam03015
      Location:357447
      Sterile; Male sterility protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_026143.2: Suppressed sequence

      Description
      NM_026143.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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