U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Armcx2 armadillo repeat containing, X-linked 2 [ Mus musculus (house mouse) ]

    Gene ID: 67416, updated on 26-Sep-2022

    Summary

    Go to the top of the page Help
    Official Symbol
    Armcx2provided by MGI
    Official Full Name
    armadillo repeat containing, X-linked 2provided by MGI
    Primary source
    MGI:MGI:1914666
    See related
    Ensembl:ENSMUSG00000033436 AllianceGenome:MGI:1914666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ALEX2; 3230401N03Rik
    Summary
    Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including brain; future brain; liver; reproductive system; and trunk. Orthologous to human ARMCX2 (armadillo repeat containing X-linked 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in ovary adult (RPKM 29.0), CNS E14 (RPKM 27.1) and 24 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Armcx2 in Genome Data Viewer
    Location:
    X; X E3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (133704891..133709970, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134804142..134809221, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing, X-linked 6 Neighboring gene microRNA 7093 Neighboring gene armadillo repeat containing, X-linked 3 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene developmental pluripotency associated 2 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo. Smith CA, et al. Dev Dyn, 2005 May. PMID 15759267
    2. The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2. López-Doménech G, et al. Nat Commun, 2012 May 8. PMID 22569362
    3. A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice. Zhou J, et al. Biol Reprod, 2013 Jun. PMID 23677977, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. has a role in specification or development of the interstitial cell lineage in the developing testis
      Title: Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    armadillo repeat-containing X-linked protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166397.1 → NP_001159869.1  armadillo repeat-containing X-linked protein 2

      See identical proteins and their annotated locations for NP_001159869.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks 5' UTR sequence, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK172960, BE986475
      Consensus CDS
      CCDS30401.1
      UniProtKB/Swiss-Prot
      Q6A058, Q9CXI9
      Related
      ENSMUSP00000108818.3, ENSMUST00000113193.9
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    2. NM_001166398.1 → NP_001159870.1  armadillo repeat-containing X-linked protein 2

      See identical proteins and their annotated locations for NP_001159870.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two different segments in its 5' UTR sequence, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK081299, AK172960, BE986475
      Consensus CDS
      CCDS30401.1
      UniProtKB/Swiss-Prot
      Q6A058, Q9CXI9
      UniProtKB/TrEMBL
      Q8BTE8
      Related
      ENSMUSP00000049147.5, ENSMUST00000035559.11
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    3. NM_026139.4 → NP_080415.3  armadillo repeat-containing X-linked protein 2

      See identical proteins and their annotated locations for NP_080415.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK044926, AK053354, AK172960, BE986475
      Consensus CDS
      CCDS30401.1
      UniProtKB/Swiss-Prot
      Q6A058, Q9CXI9
      UniProtKB/TrEMBL
      Q8BJ81
      Related
      ENSMUSP00000127305.2, ENSMUST00000168264.2
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      133704891..133709970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528602.2 → XP_006528665.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006528665.1

      UniProtKB/Swiss-Prot
      Q6A058, Q9CXI9
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    2. XM_006528600.2 → XP_006528663.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006528663.1

      UniProtKB/Swiss-Prot
      Q6A058, Q9CXI9
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    3. XM_036162079.1 → XP_036017972.1  armadillo repeat-containing X-linked protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9CXI9
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ

    4. XM_006528603.3 → XP_006528666.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006528666.1

      UniProtKB/Swiss-Prot
      Q6A058, Q9CXI9
      Conserved Domains (3) summary
      sd00044
      Location:543 → 568
      HEAT; HEAT repeat [structural motif]
      pfam04826
      Location:529 → 778
      Arm_2; Armadillo-like
      NF033761
      Location:141 → 430
      gliding_GltJ; adventurous gliding motility protein GltJ
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6A058.2 GenPept UniProtKB/Swiss-Prot:Q6A058

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous