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    Bag4 BCL2-associated athanogene 4 [ Mus musculus (house mouse) ]

    Gene ID: 67384, updated on 31-Jan-2019

    Summary

    Official Symbol
    Bag4provided by MGI
    Official Full Name
    BCL2-associated athanogene 4provided by MGI
    Primary source
    MGI:MGI:1914634
    See related
    Ensembl:ENSMUSG00000037316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SODD; 2410112I15Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 6.8), mammary gland adult (RPKM 6.2) and 28 other tissues See more
    Orthologs

    Genomic context

    See Bag4 in Genome Data Viewer
    Location:
    8; 8 A2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (25764538..25785209, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (26875010..26895681, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene phospholipid phosphatase 5 Neighboring gene DDHD domain containing 2 Neighboring gene electron transferring flavoprotein, alpha polypeptide pseudogene Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene steroidogenic acute regulatory protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chaperone binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    cellular response to epidermal growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mRNA modification ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    BAG family molecular chaperone regulator 4
    Names
    BAG-4
    bcl-2-associated athanogene 4
    silencer of death domains

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026121.3NP_080397.1  BAG family molecular chaperone regulator 4

      See identical proteins and their annotated locations for NP_080397.1

      Status: VALIDATED

      Source sequence(s)
      AC156990, AC162367
      Consensus CDS
      CCDS22201.1
      UniProtKB/Swiss-Prot
      Q8CI61
      UniProtKB/TrEMBL
      A6H6S8
      Related
      ENSMUSP00000044725.8, ENSMUST00000038498.9
      Conserved Domains (1) summary
      smart00264
      Location:379456
      BAG; BAG domains, present in regulator of Hsp70 proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      25764538..25785209 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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