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    Carnmt1 carnosine N-methyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 67383, updated on 28-Oct-2024

    Summary

    Official Symbol
    Carnmt1provided by MGI
    Official Full Name
    carnosine N-methyltransferase 1provided by MGI
    Primary source
    MGI:MGI:1914633
    See related
    Ensembl:ENSMUSG00000024726 AllianceGenome:MGI:1914633
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410127L17Rik
    Summary
    Predicted to enable carnosine N-methyltransferase activity and protein homodimerization activity. Predicted to be involved in carnosine metabolic process. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; liver; and skeletal muscle. Orthologous to human CARNMT1 (carnosine N-methyltransferase 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 5.9), liver E14 (RPKM 5.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Carnmt1 in Genome Data Viewer
    Location:
    19 B; 19 13.18 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (18648099..18684565)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (18670759..18707201)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene osteoclast stimulating factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E7637 Neighboring gene nicotinamide riboside kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9992 Neighboring gene RIKEN cDNA D030056L22 gene Neighboring gene STARR-seq mESC enhancer starr_45692 Neighboring gene STARR-positive B cell enhancer ABC_E3247 Neighboring gene predicted gene, 23238 Neighboring gene transient receptor potential cation channel, subfamily M, member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables S-adenosylmethionine-dependent methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables carnosine N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables carnosine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables carnosine N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in carnosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in carnosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carnosine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    carnosine N-methyltransferase
    Names
    UPF0586 protein C9orf41 homolog
    NP_001363980.1
    NP_001363981.1
    NP_001363982.1
    NP_001363983.1
    NP_001363984.1
    NP_080396.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377051.1NP_001363980.1  carnosine N-methyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC134906
      Conserved Domains (1) summary
      pfam07942
      Location:90355
      N2227; N2227-like protein
    2. NM_001377052.1NP_001363981.1  carnosine N-methyltransferase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC134906
      Conserved Domains (1) summary
      pfam07942
      Location:83348
      N2227; N2227-like protein
    3. NM_001377053.1NP_001363982.1  carnosine N-methyltransferase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC134906
      Conserved Domains (1) summary
      pfam07942
      Location:135333
      N2227; N2227-like protein
    4. NM_001377054.1NP_001363983.1  carnosine N-methyltransferase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC134906
      Conserved Domains (1) summary
      pfam07942
      Location:90288
      N2227; N2227-like protein
    5. NM_001377055.1NP_001363984.1  carnosine N-methyltransferase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC134906
      Conserved Domains (1) summary
      pfam07942
      Location:83281
      N2227; N2227-like protein
    6. NM_026120.5NP_080396.2  carnosine N-methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_080396.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC134906
      Consensus CDS
      CCDS29689.1
      UniProtKB/Swiss-Prot
      Q80UY1, Q9CWF3
      Related
      ENSMUSP00000025632.10, ENSMUST00000025632.11
      Conserved Domains (1) summary
      pfam07942
      Location:135400
      N2227; N2227-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      18648099..18684565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004940170.1 RNA Sequence

    2. XR_004940171.1 RNA Sequence