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    Brd3 bromodomain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 67382, updated on 3-Feb-2019

    Summary

    Official Symbol
    Brd3provided by MGI
    Official Full Name
    bromodomain containing 3provided by MGI
    Primary source
    MGI:MGI:1914632
    See related
    Ensembl:ENSMUSG00000026918
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORFX; Fsrg2; RINGL3; AW060456; 2410084F24Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.9), limb E14.5 (RPKM 14.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Brd3 in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (27445576..27507657, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (27301101..27331193, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene vav 2 oncogene Neighboring gene bromodomain containing 3, opposite strand Neighboring gene microRNA 7578 Neighboring gene makorin, ring finger protein, 1 pseudogene Neighboring gene uncharacterized LOC105244102 Neighboring gene WD repeat domain 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    lysine-acetylated histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    bromodomain-containing protein 3
    Names
    bromodomain-containing FSH-like protein FSRG2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113573.1NP_001107045.1  bromodomain-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001107045.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal coding exon, as compared to vairant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK034797, AK079666, AK160752, BM899753, BY064662
      Consensus CDS
      CCDS15828.1
      UniProtKB/Swiss-Prot
      Q8K2F0
      UniProtKB/TrEMBL
      Q3TUI3
      Related
      ENSMUSP00000076918.6, ENSMUST00000077737.12
      Conserved Domains (3) summary
      cd05497
      Location:33139
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:310411
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:572636
      BET; Bromodomain extra-terminal - transcription regulation
    2. NM_001113574.1NP_001107046.1  bromodomain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001107046.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK034797, AK037435, AK076472, AK079666, AK160752, BM899753, BY064662
      Consensus CDS
      CCDS50546.1
      UniProtKB/Swiss-Prot
      Q8K2F0
      UniProtKB/TrEMBL
      Q3TUI3, Q5CCJ9
      Related
      ENSMUSP00000109574.2, ENSMUST00000113941.8
      Conserved Domains (3) summary
      cd05497
      Location:33139
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:310411
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:589653
      BET; Bromodomain extra-terminal - transcription regulation
    3. NM_023336.4NP_075825.3  bromodomain-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_075825.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate 5' UTR and lacks an internal coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AK034797, AK079666, AK160752, BE981816, BM899753, CN530570
      Consensus CDS
      CCDS15828.1
      UniProtKB/Swiss-Prot
      Q8K2F0
      UniProtKB/TrEMBL
      Q3TUI3
      Related
      ENSMUSP00000028282.8, ENSMUST00000028282.14
      Conserved Domains (3) summary
      cd05497
      Location:33139
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:310411
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:572636
      BET; Bromodomain extra-terminal - transcription regulation

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      27445576..27507657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498250.2XP_006498313.1  bromodomain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006498313.1

      UniProtKB/TrEMBL
      Q5CCJ9
      Related
      ENSMUSP00000114422.1, ENSMUST00000154316.7
      Conserved Domains (3) summary
      cd05497
      Location:33139
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:310411
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:589653
      BET; Bromodomain extra-terminal - transcription regulation
    2. XM_006498249.3XP_006498312.1  bromodomain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006498312.1

      UniProtKB/TrEMBL
      Q5CCJ9
      Conserved Domains (3) summary
      cd05497
      Location:33139
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:310411
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:589653
      BET; Bromodomain extra-terminal - transcription regulation
    3. XM_011239156.2XP_011237458.1  bromodomain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011237458.1

      UniProtKB/TrEMBL
      Q5CCJ9
      Conserved Domains (3) summary
      cd05497
      Location:33139
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:310411
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:589653
      BET; Bromodomain extra-terminal - transcription regulation
    4. XM_011239157.2XP_011237459.1  bromodomain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011237459.1

      UniProtKB/TrEMBL
      Q5CCJ9
      Conserved Domains (3) summary
      cd05497
      Location:33139
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:310411
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:589653
      BET; Bromodomain extra-terminal - transcription regulation
    5. XM_011239155.2XP_011237457.1  bromodomain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011237457.1

      UniProtKB/TrEMBL
      Q5CCJ9
      Conserved Domains (3) summary
      cd05497
      Location:33139
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:310411
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:589653
      BET; Bromodomain extra-terminal - transcription regulation
    6. XM_011239158.2XP_011237460.1  bromodomain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011237460.1

      UniProtKB/TrEMBL
      Q5CCJ9
      Conserved Domains (3) summary
      cd05497
      Location:33139
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:310411
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:589653
      BET; Bromodomain extra-terminal - transcription regulation
    7. XM_011239159.2XP_011237461.1  bromodomain-containing protein 3 isoform X2

      Conserved Domains (2) summary
      cd05498
      Location:191
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:269333
      BET; Bromodomain extra-terminal - transcription regulation
    8. XM_017319221.1XP_017174710.1  bromodomain-containing protein 3 isoform X3

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