Format

Send to:

Choose Destination
    • Showing Current items.

    SRP54 signal recognition particle 54 [ Homo sapiens (human) ]

    Gene ID: 6729, updated on 8-Jul-2021

    Summary

    Official Symbol
    SRP54provided by HGNC
    Official Full Name
    signal recognition particle 54provided by HGNC
    Primary source
    HGNC:HGNC:11301
    See related
    Ensembl:ENSG00000100883 MIM:604857
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCN8
    Expression
    Ubiquitous expression in testis (RPKM 26.2), thyroid (RPKM 18.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SRP54 in Genome Data Viewer
    Location:
    14q13.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (34982981..35029567)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (35452198..35498773)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene bromodomain adjacent to zinc finger domain 1A Neighboring gene BAZ1A antisense RNA 1 Neighboring gene SRP54 antisense RNA 1 Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 1 Neighboring gene family with sequence similarity 177 member A1 Neighboring gene uncharacterized LOC101927178 Neighboring gene protein phosphatase 2 regulatory subunit B''gamma Neighboring gene protein only RNase P catalytic subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, signal recognition particle 54kDa (SRP54), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 7S RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables endoplasmic reticulum signal peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables endoplasmic reticulum signal peptide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribonucleoprotein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of signal recognition particle, endoplasmic reticulum targeting IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    signal recognition particle 54 kDa protein
    Names
    signal recognition particle 54kD
    signal recognition particle 54kDa
    NP_001139754.1
    NP_003127.1
    XP_005268081.1
    XP_011535408.1
    XP_016877104.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146282.2NP_001139754.1  signal recognition particle 54 kDa protein isoform 2

      See identical proteins and their annotated locations for NP_001139754.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 5' coding region and uses a distinct translational start codon, compared to variant 1. The resulting isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK300824, BC000652, DA495064
      UniProtKB/Swiss-Prot
      P61011
      Related
      ENSP00000451775.1, ENST00000555557.5
      Conserved Domains (1) summary
      TIGR01425
      Location:8381
      SRP54_euk; signal recognition particle protein SRP54
    2. NM_003136.4NP_003127.1  signal recognition particle 54 kDa protein isoform 1

      See identical proteins and their annotated locations for NP_003127.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC000652, DA495064
      Consensus CDS
      CCDS9652.1
      UniProtKB/Swiss-Prot
      P61011
      Related
      ENSP00000216774.6, ENST00000216774.11
      Conserved Domains (1) summary
      TIGR01425
      Location:2430
      SRP54_euk; signal recognition particle protein SRP54

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

      Range
      34982981..35029567
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005268024.3XP_005268081.1  signal recognition particle 54 kDa protein isoform X2

      Related
      ENSP00000451647.2, ENST00000555746.6
      Conserved Domains (1) summary
      TIGR01425
      Location:2385
      SRP54_euk; signal recognition particle protein SRP54
    2. XM_017021615.2XP_016877104.1  signal recognition particle 54 kDa protein isoform X3

      Conserved Domains (1) summary
      TIGR01425
      Location:1326
      SRP54_euk; signal recognition particle protein SRP54
    3. XM_011537106.1XP_011535408.1  signal recognition particle 54 kDa protein isoform X1

      See identical proteins and their annotated locations for XP_011535408.1

      UniProtKB/Swiss-Prot
      P61011
      Related
      ENSP00000504673.1, ENST00000677647.1
      Conserved Domains (1) summary
      TIGR01425
      Location:2430
      SRP54_euk; signal recognition particle protein SRP54
    Support Center