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    Slc25a19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 [ Mus musculus (house mouse) ]

    Gene ID: 67283, updated on 23-Jun-2021

    Summary

    Official Symbol
    Slc25a19provided by MGI
    Official Full Name
    solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19provided by MGI
    Primary source
    MGI:MGI:1914533
    See related
    Ensembl:ENSMUSG00000020744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DN; TP; DNC; MUP; TPC; MUP1; 2900089E13Rik
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 38.7), mammary gland adult (RPKM 32.6) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Slc25a19 in Genome Data Viewer
    Location:
    11; 11 E2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115504991..115519122, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (115614165..115628296, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (115476297..115489453, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene predicted gene, 25364 Neighboring gene mitchondrial ribosomal protein S7 Neighboring gene MIF4G domain containing Neighboring gene growth factor receptor bound protein 2 Neighboring gene predicted gene, 42096 Neighboring gene predicted gene 11703

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables thiamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in thiamine pyrophosphate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    mitochondrial thiamine pyrophosphate carrier
    Names
    solute carrier family 25 (mitochondrial deoxynucleotide carrier), member 19
    solute carrier family 25 member 19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252384.1NP_001239313.1  mitochondrial thiamine pyrophosphate carrier isoform 1

      See identical proteins and their annotated locations for NP_001239313.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform 1.
      Source sequence(s)
      AK005710, AV155885, BY276424, CA322885, CF584740, CX241396
      Consensus CDS
      CCDS25644.1
      UniProtKB/Swiss-Prot
      Q9DAM5
      Related
      ENSMUSP00000137534.2, ENSMUST00000178003.8
      Conserved Domains (1) summary
      pfam00153
      Location:118203
      Mito_carr; Mitochondrial carrier protein
    2. NM_001252394.1NP_001239323.1  mitochondrial thiamine pyrophosphate carrier isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' region and another exon in the 3' region, compared to variant 1. The absence of the exon in the 3' region results in a frameshift. The resulting isoform (2) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AV155885, BC046767, BY276424, CA322885, CF584740
      Consensus CDS
      CCDS56819.1
      UniProtKB/TrEMBL
      A2A9V5, Q80XJ6
      Related
      ENSMUSP00000102112.4, ENSMUST00000106503.10
      Conserved Domains (1) summary
      pfam00153
      Location:16108
      Mito_carr; Mitochondrial carrier protein
    3. NM_001252395.1NP_001239324.1  mitochondrial thiamine pyrophosphate carrier isoform 3

      See identical proteins and their annotated locations for NP_001239324.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an additional exon in the 5' coding region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK005710, AV155885, BI736130, BY276424, CA322885, CF584740
      UniProtKB/Swiss-Prot
      Q9DAM5
      Conserved Domains (1) summary
      pfam00153
      Location:26111
      Mito_carr; Mitochondrial carrier protein
    4. NM_001252396.1NP_001239325.1  mitochondrial thiamine pyrophosphate carrier isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an exon in the 5' coding region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AV155885, BC046767, BY276424, CA322885, CF584740, CF730205
      UniProtKB/TrEMBL
      Q80XJ6
      Conserved Domains (1) summary
      pfam00153
      Location:48147
      Mito_carr; Mitochondrial carrier protein
    5. NM_026071.3NP_080347.1  mitochondrial thiamine pyrophosphate carrier isoform 1

      See identical proteins and their annotated locations for NP_080347.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is a predominant transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK005710, AV155885, BY276424, CA322885, CF584740
      Consensus CDS
      CCDS25644.1
      UniProtKB/Swiss-Prot
      Q9DAM5
      Related
      ENSMUSP00000021089.5, ENSMUST00000021089.11
      Conserved Domains (1) summary
      pfam00153
      Location:118203
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115504991..115519122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249183.3XP_011247485.1  mitochondrial thiamine pyrophosphate carrier isoform X3

      See identical proteins and their annotated locations for XP_011247485.1

      Related
      ENSMUSP00000114566.2, ENSMUST00000135552.2
      Conserved Domains (1) summary
      pfam00153
      Location:26111
      Mito_carr; Mitochondrial carrier protein
    2. XM_036156904.1XP_036012797.1  mitochondrial thiamine pyrophosphate carrier isoform X4

      Conserved Domains (1) summary
      pfam00153
      Location:48147
      Mito_carr; Mitochondrial carrier protein
    3. XM_036156903.1XP_036012796.1  mitochondrial thiamine pyrophosphate carrier isoform X3

      Conserved Domains (1) summary
      pfam00153
      Location:26111
      Mito_carr; Mitochondrial carrier protein
    4. XM_036156902.1XP_036012795.1  mitochondrial thiamine pyrophosphate carrier isoform X1

      Conserved Domains (1) summary
      pfam00153
      Location:118203
      Mito_carr; Mitochondrial carrier protein
    5. XM_030246244.1XP_030102104.1  mitochondrial thiamine pyrophosphate carrier isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:16108
      Mito_carr; Mitochondrial carrier protein
    6. XM_030246245.1XP_030102105.1  mitochondrial thiamine pyrophosphate carrier isoform X3

      Conserved Domains (1) summary
      pfam00153
      Location:26111
      Mito_carr; Mitochondrial carrier protein
    7. XM_006533979.4XP_006534042.1  mitochondrial thiamine pyrophosphate carrier isoform X1

      See identical proteins and their annotated locations for XP_006534042.1

      UniProtKB/Swiss-Prot
      Q9DAM5
      Conserved Domains (1) summary
      pfam00153
      Location:118203
      Mito_carr; Mitochondrial carrier protein
    8. XM_017314714.2XP_017170203.1  mitochondrial thiamine pyrophosphate carrier isoform X1

      UniProtKB/Swiss-Prot
      Q9DAM5
      Conserved Domains (1) summary
      pfam00153
      Location:118203
      Mito_carr; Mitochondrial carrier protein
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