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    SRM spermidine synthase [ Homo sapiens (human) ]

    Gene ID: 6723, updated on 5-May-2024

    Summary

    Official Symbol
    SRMprovided by HGNC
    Official Full Name
    spermidine synthaseprovided by HGNC
    Primary source
    HGNC:HGNC:11296
    See related
    Ensembl:ENSG00000116649 MIM:182891; AllianceGenome:HGNC:11296
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAPT; SPS1; SPDSY; SRML1
    Summary
    The polyamines putrescine, spermine, and spermidine are ubiquitous polycationic mediators of cell growth and differentiation. Spermidine synthase is one of four enzymes in the polyamine-biosynthetic pathway and carries out the final step of spermidine biosynthesis. This enzyme catalyzes the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in appendix (RPKM 19.8), lymph node (RPKM 14.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    Location:
    1p36.22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11054589..11060018, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (10596153..10601582, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11114646..11120075, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 258 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11072454-11073421 Neighboring gene cofilin 1 pseudogene 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11073783-11074029 Neighboring gene TAR DNA binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11105801-11106633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 159 Neighboring gene MBL associated serine protease 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 163 Neighboring gene exosome component 10 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11152350-11152530 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11159092-11159654 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11159655-11160215 Neighboring gene EXOSC10 antisense RNA 1 Neighboring gene mechanistic target of rapamycin kinase Neighboring gene MTOR antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables spermidine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables spermidine synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables spermidine synthase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to leukemia inhibitory factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in polyamine metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in spermidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spermidine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spermidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    spermidine synthase
    Names
    putrescine aminopropyltransferase
    spermidine synthase-1
    NP_003123.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003132.3NP_003123.2  spermidine synthase

      See identical proteins and their annotated locations for NP_003123.2

      Status: VALIDATED

      Source sequence(s)
      AL109811, BC000309
      Consensus CDS
      CCDS125.1
      UniProtKB/Swiss-Prot
      B1AKP9, P19623, Q15511
      Related
      ENSP00000366156.2, ENST00000376957.7
      Conserved Domains (1) summary
      PLN02366
      Location:8298
      PLN02366; spermidine synthase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      11054589..11060018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      10596153..10601582 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)