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    Prpf18 pre-mRNA processing factor 18 [ Mus musculus (house mouse) ]

    Gene ID: 67229, updated on 31-Jan-2019

    Summary

    Official Symbol
    Prpf18provided by MGI
    Official Full Name
    pre-mRNA processing factor 18provided by MGI
    Primary source
    MGI:MGI:1914479
    See related
    Ensembl:ENSMUSG00000039449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810441A10Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 11.8), placenta adult (RPKM 11.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Prpf18 in Genome Data Viewer
    Location:
    2; 2 A1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (4622058..4652144, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (4543213..4573132, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene FERM domain containing 4A Neighboring gene predicted gene, 39751 Neighboring gene predicted gene 13179 Neighboring gene ribosomal protein L22 pseudogene Neighboring gene BEN domain containing 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to second spliceosomal transesterification activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    generation of catalytic spliceosome for second transesterification step IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear retention of unspliced pre-mRNA at the site of transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    U2-type post-spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pre-mRNA-splicing factor 18
    Names
    HPRP18 homolog
    PRP18 homolog
    PRP18 pre-mRNA processing factor 18 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356451.1NP_001343380.1  pre-mRNA-splicing factor 18 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL807832, AL928550
      Conserved Domains (2) summary
      smart00500
      Location:88131
      SFM; Splicing Factor Motif, present in Prp18 and Pr04
      pfam02840
      Location:204340
      Prp18; Prp18 domain
    2. NM_026045.4NP_080321.2  pre-mRNA-splicing factor 18 isoform 2

      See identical proteins and their annotated locations for NP_080321.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI789029, BC058631, BQ176788
      Consensus CDS
      CCDS15657.1
      UniProtKB/Swiss-Prot
      Q8BM39
      Related
      ENSMUSP00000041428.7, ENSMUST00000035721.13
      Conserved Domains (2) summary
      smart00500
      Location:79122
      SFM; Splicing Factor Motif, present in Prp18 and Pr04
      pfam02840
      Location:191328
      Prp18; Prp18 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      4622058..4652144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497530.3XP_006497593.1  pre-mRNA-splicing factor 18 isoform X1

      Conserved Domains (2) summary
      smart00500
      Location:88131
      SFM; Splicing Factor Motif, present in Prp18 and Pr04
      pfam02840
      Location:204340
      Prp18; Prp18 domain
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