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    Prpf18 pre-mRNA processing factor 18 [ Mus musculus (house mouse) ]

    Gene ID: 67229, updated on 23-Jun-2021

    Summary

    Official Symbol
    Prpf18provided by MGI
    Official Full Name
    pre-mRNA processing factor 18provided by MGI
    Primary source
    MGI:MGI:1914479
    See related
    Ensembl:ENSMUSG00000039449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810441A10Rik
    Expression
    Ubiquitous expression in liver E14 (RPKM 11.8), placenta adult (RPKM 11.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Prpf18 in Genome Data Viewer
    Location:
    2; 2 A1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (4626869..4656946, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (4622058..4652135, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (4543213..4573132, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene FERM domain containing 4A Neighboring gene VISTA enhancer mm422 Neighboring gene VISTA enhancer mm423 Neighboring gene predicted gene 13179 Neighboring gene ribosomal protein L22 pseudogene Neighboring gene BEN domain containing 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of U2-type post-spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pre-mRNA-splicing factor 18
    Names
    HPRP18 homolog
    PRP18 homolog
    PRP18 pre-mRNA processing factor 18 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356451.1NP_001343380.1  pre-mRNA-splicing factor 18 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL807832, AL928550
      Conserved Domains (2) summary
      smart00500
      Location:88131
      SFM; Splicing Factor Motif, present in Prp18 and Pr04
      pfam02840
      Location:204340
      Prp18; Prp18 domain
    2. NM_026045.4NP_080321.2  pre-mRNA-splicing factor 18 isoform 2

      See identical proteins and their annotated locations for NP_080321.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AI789029, BC058631, BQ176788
      Consensus CDS
      CCDS15657.1
      UniProtKB/Swiss-Prot
      Q8BM39
      Related
      ENSMUSP00000041428.8, ENSMUST00000035721.14
      Conserved Domains (2) summary
      smart00500
      Location:79122
      SFM; Splicing Factor Motif, present in Prp18 and Pr04
      pfam02840
      Location:191328
      Prp18; Prp18 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      4626869..4656946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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