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    Nde1 nudE neurodevelopment protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 67203, updated on 8-Jul-2021

    Summary

    Official Symbol
    Nde1provided by MGI
    Official Full Name
    nudE neurodevelopment protein 1provided by MGI
    Primary source
    MGI:MGI:1914453
    See related
    Ensembl:ENSMUSG00000022678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nude; mNud; mNudE; AU042936; AW822251; 2810027M15Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 33.4), thymus adult (RPKM 23.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Nde1 in Genome Data Viewer
    Location:
    16; 16 A1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (13981139..14010792)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (14163275..14192928)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (14163368..14193021)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene meiosis regulator and mRNA stability 1 Neighboring gene microRNA 484 Neighboring gene myosin, heavy polypeptide 11, smooth muscle Neighboring gene centrosomal protein 20

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables microtubule binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in centrosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cerebral cortex development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in establishment of chromosome localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in establishment of chromosome localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within microtubule nucleation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microtubule organizing center organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic centrosome separation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within vesicle transport along microtubule IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear distribution protein nudE homolog 1
    Names
    nuclear distribution gene E homolog 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114085.1NP_001107557.1  nuclear distribution protein nudE homolog 1 isoform b

      See identical proteins and their annotated locations for NP_001107557.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant a. The encoded isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AF322073, AK012830, AK150826, BY308148
      Consensus CDS
      CCDS49770.1
      UniProtKB/Swiss-Prot
      Q9CZA6
      Related
      ENSMUSP00000112817.2, ENSMUST00000117958.8
      Conserved Domains (3) summary
      pfam04880
      Location:134309
      NUDE_C; NUDE protein, C-terminal conserved region
      pfam07926
      Location:34158
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl03075
      Location:34127
      GrpE; nucleotide exchange factor GrpE
    2. NM_001285503.1NP_001272432.1  nuclear distribution protein nudE homolog 1 isoform c

      See identical proteins and their annotated locations for NP_001272432.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant a. The encoded isoform (c) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC164291, AK146982, AW120739
      Consensus CDS
      CCDS70688.1
      UniProtKB/Swiss-Prot
      Q9CZA6
      Related
      ENSMUSP00000111461.3, ENSMUST00000115795.9
      Conserved Domains (3) summary
      pfam04880
      Location:134309
      NUDE_C; NUDE protein, C-terminal conserved region
      pfam07926
      Location:34158
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl03075
      Location:34127
      GrpE; nucleotide exchange factor GrpE
    3. NM_001285504.1NP_001272433.1  nuclear distribution protein nudE homolog 1 isoform d

      See identical proteins and their annotated locations for NP_001272433.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d) lacks an exon in the 5' end that results in the use of a downstream AUG, compared to variant a. The encoded isoform (d) has a shorter N-terminal and a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC164291, AK166858, AW120739
      UniProtKB/Swiss-Prot
      Q9CZA6
      Conserved Domains (1) summary
      pfam04880
      Location:2177
      NUDE_C; NUDE protein, C-terminal conserved region
    4. NM_023317.2NP_075806.2  nuclear distribution protein nudE homolog 1 isoform a

      See identical proteins and their annotated locations for NP_075806.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) encodes the longest isoform (a).
      Source sequence(s)
      AF322073, AK012830, BY308148
      Consensus CDS
      CCDS37263.2
      UniProtKB/Swiss-Prot
      Q9CZA6
      Related
      ENSMUSP00000023359.7, ENSMUST00000023359.13
      Conserved Domains (3) summary
      pfam04880
      Location:134309
      NUDE_C; NUDE protein, C-terminal conserved region
      pfam07926
      Location:34158
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl03075
      Location:34127
      GrpE; nucleotide exchange factor GrpE

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      13981139..14010792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160094.1XP_036015987.1  nuclear distribution protein nudE homolog 1 isoform X1

      Conserved Domains (1) summary
      pfam04880
      Location:75250
      NUDE_C; NUDE protein, C-terminal conserved region
    2. XM_036160095.1XP_036015988.1  nuclear distribution protein nudE homolog 1 isoform X2

      Conserved Domains (1) summary
      pfam04880
      Location:2177
      NUDE_C; NUDE protein, C-terminal conserved region
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