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    Ube2t ubiquitin-conjugating enzyme E2T [ Mus musculus (house mouse) ]

    Gene ID: 67196, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ube2tprovided by MGI
    Official Full Name
    ubiquitin-conjugating enzyme E2Tprovided by MGI
    Primary source
    MGI:MGI:1914446
    See related
    Ensembl:ENSMUSG00000026429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C80607; 2700084L22Rik
    Expression
    Biased expression in testis adult (RPKM 20.3), liver E14 (RPKM 12.2) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Ube2t in Genome Data Viewer
    Location:
    1; 1 E4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134890303..134901918)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134962565..134974180)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (136859154..136870714)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 12B Neighboring gene small nucleolar RNA SNORA48 Neighboring gene predicted gene, 51748 Neighboring gene microRNA 5104b Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene protein tyrosine phosphatase, receptor type, V Neighboring gene protein tyrosine phosphatase, non-receptor type 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (4) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to DNA damage stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K27-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K29-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 T
    Names
    E2 ubiquitin-conjugating enzyme T
    ubiquitin carrier protein T
    ubiquitin-conjugating enzyme E2T (putative)
    ubiquitin-protein ligase T
    NP_001265044.1
    NP_080300.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278115.1NP_001265044.1  ubiquitin-conjugating enzyme E2 T

      See identical proteins and their annotated locations for NP_001265044.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK012565, BB872310, BY576015, CK334733
      Consensus CDS
      CCDS15313.1
      UniProtKB/Swiss-Prot
      Q9CQ37
      Conserved Domains (2) summary
      COG5078
      Location:1151
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:5147
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. NM_026024.3NP_080300.1  ubiquitin-conjugating enzyme E2 T

      See identical proteins and their annotated locations for NP_080300.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK012565, BB872310, BY576015
      Consensus CDS
      CCDS15313.1
      UniProtKB/Swiss-Prot
      Q9CQ37
      Related
      ENSMUSP00000027687.8, ENSMUST00000027687.8
      Conserved Domains (2) summary
      COG5078
      Location:1151
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00195
      Location:5147
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      134890303..134901918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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