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    Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 [ Mus musculus (house mouse) ]

    Gene ID: 67184, updated on 11-Apr-2024

    Summary

    Official Symbol
    Ndufa13provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit A13provided by MGI
    Primary source
    MGI:MGI:1914434
    See related
    Ensembl:ENSMUSG00000036199 AllianceGenome:MGI:1914434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDA016; CGI-39; Grim19; GRIM-19; CI-B16.6; 2700054G14Rik
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity. Acts upstream of or within extrinsic apoptotic signaling pathway. Located in mitochondrion and nucleus. Is expressed in several structures, including alimentary system; central nervous system; heart; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 28 and thyroid gland Hurthle cell carcinoma. Orthologous to several human genes including NDUFA13 (NADH:ubiquinone oxidoreductase subunit A13). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 81.9), testis adult (RPKM 75.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ndufa13 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.03 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70346813..70355208, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69894163..69902558, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33746 Neighboring gene cartilage intermediate layer protein 2 Neighboring gene YjeF N-terminal domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E10503 Neighboring gene STARR-positive B cell enhancer ABC_E1757 Neighboring gene testis-specific serine kinase 6 Neighboring gene GATA zinc finger domain containing 2A Neighboring gene STARR-positive B cell enhancer ABC_E5012 Neighboring gene STARR-positive B cell enhancer ABC_E1367 Neighboring gene STARR-seq mESC enhancer starr_21753 Neighboring gene STARR-seq mESC enhancer starr_21758 Neighboring gene STARR-positive B cell enhancer ABC_E89 Neighboring gene STARR-seq mESC enhancer starr_21762 Neighboring gene nucleoside diphosphate kinase B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein insertion into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial respirasome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of mitochondrial respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of mitochondrial respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
    Names
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
    NADH-ubiquinone oxidoreductase B16.6 subunit
    cell death regulatory protein GRIM-19
    complex I-B16.6
    gene associated with retinoic and IFN-induced mortality 19 protein
    gene associated with retinoic and interferon-induced mortality 19 protein
    gene associated with retinoic-interferon-induced mortality 19 protein
    genes associated with retinoid-IFN-induced mortality 19
    NP_001369144.1
    NP_001408485.1
    NP_075801.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001382215.1NP_001369144.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

      Status: VALIDATED

      Source sequence(s)
      AC158564
      UniProtKB/Swiss-Prot
      Q9DC98, Q9DCA1, Q9ERS2
      Conserved Domains (1) summary
      pfam06212
      Location:5128
      GRIM-19; GRIM-19 protein
    2. NM_001421556.1NP_001408485.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

      Status: VALIDATED

      Source sequence(s)
      AC158564
      UniProtKB/Swiss-Prot
      Q9DC98, Q9DCA1, Q9ERS2
    3. NM_023312.3NP_075801.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

      See identical proteins and their annotated locations for NP_075801.1

      Status: VALIDATED

      Source sequence(s)
      AC158564
      Consensus CDS
      CCDS22353.1
      UniProtKB/Swiss-Prot
      Q9DC98, Q9DCA1, Q9ERS2
      Related
      ENSMUSP00000105796.4, ENSMUST00000110167.5
      Conserved Domains (1) summary
      pfam06212
      Location:5128
      GRIM-19; GRIM-19 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70346813..70355208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)