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    Cdt1 chromatin licensing and DNA replication factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 67177, updated on 25-Nov-2021

    Summary

    Official Symbol
    Cdt1provided by MGI
    Official Full Name
    chromatin licensing and DNA replication factor 1provided by MGI
    Primary source
    MGI:MGI:1914427
    See related
    Ensembl:ENSMUSG00000006585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DUP; Ris2; C76791; AW545653; 2610318F11Rik
    Expression
    Broad expression in thymus adult (RPKM 48.2), liver E14.5 (RPKM 44.9) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cdt1 in Genome Data Viewer
    Location:
    8; 8 E1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123294754..123299869)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122568015..122573130)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (125091915..125097030)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene piezo-type mechanosensitive ion channel component 1 Neighboring gene predicted gene, 26497 Neighboring gene predicted gene, 34847 Neighboring gene adenine phosphoribosyl transferase Neighboring gene galactosamine (N-acetyl)-6-sulfate sulfatase Neighboring gene predicted gene, 34962

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA polymerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA replication checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA replication preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA replication preinitiation complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in deactivation of mitotic spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kinetochore organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-dependent DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-dependent DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA replication origin binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-dependent DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of DNA-dependent DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-dependent DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chromosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of nuclear cell cycle DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to sorbitol ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA replication factor Cdt1
    Names
    double parked homolog
    retroviral insertion site 2 protein
    retroviral integration site 1
    retroviral integration site 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026014.3NP_080290.3  DNA replication factor Cdt1

      See identical proteins and their annotated locations for NP_080290.3

      Status: VALIDATED

      Source sequence(s)
      BC048076
      Consensus CDS
      CCDS22741.1
      UniProtKB/Swiss-Prot
      Q8R4E9
      Related
      ENSMUSP00000006760.3, ENSMUST00000006760.3
      Conserved Domains (2) summary
      cd08674
      Location:181364
      Cdt1_m; The middle winged helix fold of replication licensing factor Cdt1 binds geminin to inhibit binding of the MCM complex to origins of replication and DNA
      cd08767
      Location:427549
      Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      123294754..123299869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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