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    Mtdh metadherin [ Mus musculus (house mouse) ]

    Gene ID: 67154, updated on 26-Jul-2021

    Summary

    Official Symbol
    Mtdhprovided by MGI
    Official Full Name
    metadherinprovided by MGI
    Primary source
    MGI:MGI:1914404
    See related
    Ensembl:ENSMUSG00000022255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly; 3D3; AEG-; AEG-1; Lyric; 3D3/Ly; AV353288; 3D3/Lyric; D8Bwg1112e; 2610103J23Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 15.3), bladder adult (RPKM 13.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mtdh in Genome Data Viewer
    Location:
    15 B3.1; 15 13.98 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34082613..34143683)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34082442..34143537)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (34012474..34072140)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9643 Neighboring gene predicted gene, 41290 Neighboring gene predicted gene, 41291 Neighboring gene predicted gene, 38594 Neighboring gene lysosomal-associated protein transmembrane 4B Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NF-kappaB binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein LYRIC
    Names
    lysine-rich CEACAM1 co-isolated protein
    metastasis adhesion protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357925.1NP_001344854.1  protein LYRIC isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks exons in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC149588
      Conserved Domains (1) summary
      pfam15686
      Location:6386
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    2. NM_001357926.1NP_001344855.1  protein LYRIC isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC149588
      Conserved Domains (1) summary
      pfam15686
      Location:6449
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    3. NM_026002.5NP_080278.3  protein LYRIC isoform 3

      See identical proteins and their annotated locations for NP_080278.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC149588
      Consensus CDS
      CCDS27415.1
      UniProtKB/Swiss-Prot
      Q80WJ7
      Related
      ENSMUSP00000022865.10, ENSMUST00000022865.17
      Conserved Domains (1) summary
      pfam15686
      Location:6419
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      34082613..34143683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520151.3XP_006520214.1  protein LYRIC isoform X2

      Conserved Domains (1) summary
      pfam15686
      Location:6449
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    2. XM_017316729.3XP_017172218.1  protein LYRIC isoform X4

      Conserved Domains (1) summary
      pfam15686
      Location:6419
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    3. XM_006520152.3XP_006520215.1  protein LYRIC isoform X7

      Related
      ENSMUSP00000130190.3, ENSMUST00000163333.9
      Conserved Domains (1) summary
      pfam15686
      Location:6386
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    4. XM_006520149.3XP_006520212.1  protein LYRIC isoform X1

      Conserved Domains (1) summary
      pfam15686
      Location:6390
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    5. XM_017316731.3XP_017172220.1  protein LYRIC isoform X6

      Conserved Domains (1) summary
      pfam15686
      Location:6390
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    6. XM_017316728.3XP_017172217.1  protein LYRIC isoform X3

      Conserved Domains (1) summary
      pfam15686
      Location:6360
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    7. XM_017316730.3XP_017172219.1  protein LYRIC isoform X5

      Conserved Domains (1) summary
      pfam15686
      Location:6327
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    8. XM_030248710.1XP_030104570.1  protein LYRIC isoform X8

      Related
      ENSMUSP00000131814.2, ENSMUST00000169905.2
      Conserved Domains (1) summary
      pfam15686
      Location:12208
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
    9. XM_036159548.1XP_036015441.1  protein LYRIC isoform X9

      Conserved Domains (1) summary
      pfam15686
      Location:12175
      LYRIC; Lysine-rich CEACAM1 co-isolated protein family
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