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    Fbxo5 F-box protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 67141, updated on 23-Jun-2021

    Summary

    Official Symbol
    Fbxo5provided by MGI
    Official Full Name
    F-box protein 5provided by MGI
    Primary source
    MGI:MGI:1914391
    See related
    Ensembl:ENSMUSG00000019773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Emi; Emi1; Fbxo3; C85305; Fbxo31; 2510044I10Rik
    Expression
    Biased expression in liver E14 (RPKM 31.2), liver E14.5 (RPKM 24.6) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fbxo5 in Genome Data Viewer
    Location:
    10; 10 A1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (5749155..5755465, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (5799158..5805465, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (4541076..4547383)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47679 Neighboring gene predicted gene, 30617 Neighboring gene predicted gene, 53609 Neighboring gene mitochondrial translational release factor 1-like Neighboring gene regulator of G-protein signaling 17 Neighboring gene predicted gene, 18902

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables anaphase-promoting complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin ligase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within microtubule polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA endoreduplication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of meiotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of meiotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oocyte maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of biomineral tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of meiosis I ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of mesenchymal stem cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of meiotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic nuclear division IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within spindle assembly involved in female meiosis I IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within vesicle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    F-box only protein 5
    Names
    early mitotic inhibitor 1
    f-box only protein 31

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025995.2NP_080271.2  F-box only protein 5

      See identical proteins and their annotated locations for NP_080271.2

      Status: VALIDATED

      Source sequence(s)
      AC159325, BC053434
      Consensus CDS
      CCDS56683.1
      UniProtKB/Swiss-Prot
      Q7TSG3
      Related
      ENSMUSP00000019907.8, ENSMUST00000019907.8
      Conserved Domains (1) summary
      smart00256
      Location:232264
      FBOX; A Receptor for Ubiquitination Targets

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      5749155..5755465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155959.1XP_036011852.1  F-box only protein 5 isoform X1

      Conserved Domains (2) summary
      smart00256
      Location:194226
      FBOX; A Receptor for Ubiquitination Targets
      pfam01485
      Location:302352
      IBR; IBR domain, a half RING-finger domain
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