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    Mis12 MIS12 kinetochore complex component [ Mus musculus (house mouse) ]

    Gene ID: 67139, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mis12provided by MGI
    Official Full Name
    MIS12 kinetochore complex componentprovided by MGI
    Primary source
    MGI:MGI:1914389
    See related
    Ensembl:ENSMUSG00000040599
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Misc12; AU044651; 2510025F08Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 10.8), liver E14 (RPKM 7.9) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Mis12 in Genome Data Viewer
    Location:
    11; 11 B4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70910394..70918197)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (71019568..71027371)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (70833113..70840636)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RPA interacting protein Neighboring gene complement component 1, q subcomponent binding protein Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 33 Neighboring gene predicted gene, 22297 Neighboring gene Der1-like domain family, member 2 Neighboring gene RIKEN cDNA 6330403K07 gene Neighboring gene RNA binding motif protein 7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kinetochore assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in kinetochore assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein localization to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of MIS12/MIND type complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear MIS12/MIND complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein MIS12 homolog
    Names
    MIS12 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025993.3NP_080269.1  protein MIS12 homolog

      See identical proteins and their annotated locations for NP_080269.1

      Status: VALIDATED

      Source sequence(s)
      AL596136
      Consensus CDS
      CCDS24973.1
      UniProtKB/Swiss-Prot
      Q9CY25
      Related
      ENSMUSP00000039500.6, ENSMUST00000048807.12
      Conserved Domains (1) summary
      pfam05859
      Location:8140
      Mis12; Mis12 protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70910394..70918197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533968.3XP_006534031.1  protein MIS12 homolog isoform X1

      See identical proteins and their annotated locations for XP_006534031.1

      UniProtKB/Swiss-Prot
      Q9CY25
      Conserved Domains (1) summary
      pfam05859
      Location:8140
      Mis12; Mis12 protein
    2. XM_006533969.3XP_006534032.1  protein MIS12 homolog isoform X1

      See identical proteins and their annotated locations for XP_006534032.1

      UniProtKB/Swiss-Prot
      Q9CY25
      Conserved Domains (1) summary
      pfam05859
      Location:8140
      Mis12; Mis12 protein
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