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    Bfar bifunctional apoptosis regulator [ Mus musculus (house mouse) ]

    Gene ID: 67118, updated on 31-Jan-2019

    Summary

    Official Symbol
    Bfarprovided by MGI
    Official Full Name
    bifunctional apoptosis regulatorprovided by MGI
    Primary source
    MGI:MGI:1914368
    See related
    Ensembl:ENSMUSG00000022684 Ensembl:ENSMUSG00000079737
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bar; Rnf47; AI666707; AW107665; 3010001A07Rik; 3110001I22Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 14.9), subcutaneous fat pad adult (RPKM 12.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Bfar in Genome Data Viewer
    Location:
    16; 16 A1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (13671858..13703612)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (13671951..13703705)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310015D24 gene Neighboring gene poly(A)-specific ribonuclease (deadenylation nuclease) Neighboring gene predicted gene, 33329 Neighboring gene phospholipase A2, group X Neighboring gene phospholipase A2, group X, opposite strand Neighboring gene RIKEN cDNA A930007A09 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC48147

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    caspase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding, bridging ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    negative regulation of IRE1-mediated unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bifunctional apoptosis regulator

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177552.1NP_001171023.1  bifunctional apoptosis regulator isoform 2

      See identical proteins and their annotated locations for NP_001171023.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons, resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC154607, AI255749, AK028592
      Consensus CDS
      CCDS49769.1
      UniProtKB/Swiss-Prot
      Q8R079
      Related
      ENSMUSP00000063371.7, ENSMUST00000069281.7
      Conserved Domains (2) summary
      cd00162
      Location:3477
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cl15755
      Location:98124
      SAM_superfamily; SAM (Sterile alpha motif )
    2. NM_025653.3NP_079929.1  bifunctional apoptosis regulator isoform 3

      See identical proteins and their annotated locations for NP_079929.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences compared to variant 1. The encoded isoform (3) is completely distinct from isoform 1.
      Source sequence(s)
      AC154607, AK012939, AW121701, BB613414, BY777666
      Consensus CDS
      CCDS37260.1
      UniProtKB/TrEMBL
      Q9CZ70
      Related
      ENSMUSP00000041742.5, ENSMUST00000035426.6
      Conserved Domains (1) summary
      pfam11488
      Location:246300
      Lge1; Transcriptional regulatory protein LGE1
    3. NM_025976.5NP_080252.1  bifunctional apoptosis regulator isoform 1

      See identical proteins and their annotated locations for NP_080252.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC154607, AI255749, AK013874
      Consensus CDS
      CCDS27966.1
      UniProtKB/Swiss-Prot
      Q8R079
      UniProtKB/TrEMBL
      A0A0R4J040
      Related
      ENSMUSP00000023365.6, ENSMUST00000023365.12
      Conserved Domains (3) summary
      cd09513
      Location:179249
      SAM_BAR; SAM domain of BAR subfamily
      smart00454
      Location:179248
      SAM; Sterile alpha motif
      cd00162
      Location:3477
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      13671858..13703612
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    2. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      13672020..13678385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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