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    Ctnnbip1 catenin beta interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 67087, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ctnnbip1provided by MGI
    Official Full Name
    catenin beta interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1915756
    See related
    Ensembl:ENSMUSG00000028988
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IC; Catn; Icat; AW457332; Catnbip1; 1110008O09Rik; 2310001I19Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 19.3), whole brain E14.5 (RPKM 17.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ctnnbip1 in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149602698..149650894)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149518241..149566437)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (148892350..148940546)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene nicotinamide nucleotide adenylyltransferase 1 Neighboring gene leucine zipper and CTNNBIP1 domain containing Neighboring gene predicted gene, 24381 Neighboring gene microRNA 5616 Neighboring gene calsyntenin 1 Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Neighboring gene microRNA 7023

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables armadillo repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of mesenchymal cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription initiation from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of monocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of vascular permeability involved in acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of beta-catenin destruction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of beta-catenin destruction complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    beta-catenin-interacting protein 1
    Names
    inhibitor of beta-catenin and Tcf-4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001141930.1NP_001135402.1  beta-catenin-interacting protein 1

      See identical proteins and their annotated locations for NP_001135402.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK003595, AK048258, BQ031304, BQ043263
      Consensus CDS
      CCDS38975.1
      UniProtKB/Swiss-Prot
      Q9JJN6
      Related
      ENSMUSP00000101317.2, ENSMUST00000105692.2
      Conserved Domains (1) summary
      pfam06384
      Location:179
      ICAT; Beta-catenin-interacting protein ICAT
    2. NM_023465.4NP_075954.1  beta-catenin-interacting protein 1

      See identical proteins and their annotated locations for NP_075954.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK036181, BQ031304
      Consensus CDS
      CCDS38975.1
      UniProtKB/Swiss-Prot
      Q9JJN6
      Related
      ENSMUSP00000030839.7, ENSMUST00000030839.13
      Conserved Domains (1) summary
      pfam06384
      Location:179
      ICAT; Beta-catenin-interacting protein ICAT

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      149602698..149650894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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