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    Cdc37l1 cell division cycle 37-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 67072, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdc37l1provided by MGI
    Official Full Name
    cell division cycle 37-like 1provided by MGI
    Primary source
    MGI:MGI:1914322
    See related
    Ensembl:ENSMUSG00000024780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Harc; Cdc37l; BB159850; 2700033A15Rik
    Summary
    This gene encodes a protein related to the Hsp90 co-chaperone Cdc37. This protein may have a role in mediating interactions between the Hsp90 complex and other proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 8.6), cortex adult (RPKM 6.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdc37l1 in Genome Data Viewer
    Location:
    19; 19 C1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (28990318..29026680)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (29064984..29092059)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene phytanoyl-CoA hydroxylase pseudogene Neighboring gene tektin 5 pseudogene Neighboring gene adenylate kinase 3 Neighboring gene ribosomal protein L26 pseudogene Neighboring gene RIKEN cDNA 1700018L02 gene Neighboring gene predicted gene 9895

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hsp90 co-chaperone Cdc37-like 1
    Names
    Hsp90-associating relative of Cdc37
    cell division cycle 37 homolog-like 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302380.1NP_001289309.1  hsp90 co-chaperone Cdc37-like 1 isoform 2

      See identical proteins and their annotated locations for NP_001289309.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK016651, AK048044, AK078468, BE949427
      UniProtKB/Swiss-Prot
      Q9CZP7
      Related
      ENSMUSP00000152985.1, ENSMUST00000224511.1
      Conserved Domains (2) summary
      smart01070
      Location:138280
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71139
      CDC37_N; Cdc37 N terminal kinase binding
    2. NM_001302382.1NP_001289311.1  hsp90 co-chaperone Cdc37-like 1 isoform 3

      See identical proteins and their annotated locations for NP_001289311.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and 3' UTR. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK016651, AK078468, AK078872, AK079556, BE947539
      UniProtKB/Swiss-Prot
      Q9CZP7
      Related
      ENSMUSP00000153192.1, ENSMUST00000225310.1
      Conserved Domains (2) summary
      smart01070
      Location:138280
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71139
      CDC37_N; Cdc37 N terminal kinase binding
    3. NM_001302443.1NP_001289372.1  hsp90 co-chaperone Cdc37-like 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA472267, AC113961, AK016651, AK078139, AK078468, BP762769
      UniProtKB/Swiss-Prot
      Q9CZP7
      Conserved Domains (2) summary
      smart01070
      Location:138280
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71139
      CDC37_N; Cdc37 N terminal kinase binding
    4. NM_025950.3NP_080226.1  hsp90 co-chaperone Cdc37-like 1 isoform 1

      See identical proteins and their annotated locations for NP_080226.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC113961, AK012312, AK016651, AK078468, BP762769
      Consensus CDS
      CCDS29729.1
      UniProtKB/Swiss-Prot
      Q9CZP7
      Related
      ENSMUSP00000060421.3, ENSMUST00000050148.4
      Conserved Domains (2) summary
      smart01070
      Location:138280
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71139
      CDC37_N; Cdc37 N terminal kinase binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      28990318..29026680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527271.3XP_006527334.1  hsp90 co-chaperone Cdc37-like 1 isoform X1

      Conserved Domains (2) summary
      smart01070
      Location:138280
      CDC37_M; Cdc37 Hsp90 binding domain
      cl03951
      Location:71139
      CDC37_N; Cdc37 N terminal kinase binding

    RNA

    1. XR_386500.3 RNA Sequence

    2. XR_877687.2 RNA Sequence

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