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    Romo1 reactive oxygen species modulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 67067, updated on 31-Jan-2019

    Summary

    Official Symbol
    Romo1provided by MGI
    Official Full Name
    reactive oxygen species modulator 1provided by MGI
    Primary source
    MGI:MGI:1914317
    See related
    Ensembl:ENSMUSG00000067847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI853864; 2010100O12Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 102.7), adrenal adult (RPKM 88.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Romo1 in Genome Data Viewer
    Location:
    2; 2 H1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (156144153..156145794)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (155969889..155971530)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 4 Neighboring gene copine I Neighboring gene RNA binding motif protein 12 Neighboring gene nitrogen fixation gene 1 (S. cerevisiae) Neighboring gene RNA binding motif protein 39 Neighboring gene PHD finger protein 20

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    cytolysis in other organism ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    killing of cells of other organism ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein import into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    replicative cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    reactive oxygen species modulator 1
    Names
    ROS modulator 1
    protein MGR2 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164216.1NP_001157688.1  reactive oxygen species modulator 1

      See identical proteins and their annotated locations for NP_001157688.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA058111, AK008300, BE996606
      Consensus CDS
      CCDS38296.1
      UniProtKB/Swiss-Prot
      P60603
      Related
      ENSMUSP00000085981.4, ENSMUST00000088610.10
      Conserved Domains (1) summary
      pfam10247
      Location:1479
      Romo1; Reactive mitochondrial oxygen species modulator 1
    2. NM_001164217.2NP_001157689.1  reactive oxygen species modulator 1

      See identical proteins and their annotated locations for NP_001157689.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AA058111, BC028749, CJ221444
      Consensus CDS
      CCDS38296.1
      UniProtKB/Swiss-Prot
      P60603
      Related
      ENSMUSP00000113943.1, ENSMUST00000119950.1
      Conserved Domains (1) summary
      pfam10247
      Location:1479
      Romo1; Reactive mitochondrial oxygen species modulator 1
    3. NM_025946.6NP_080222.1  reactive oxygen species modulator 1

      See identical proteins and their annotated locations for NP_080222.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC028749, EL963857
      Consensus CDS
      CCDS38296.1
      UniProtKB/Swiss-Prot
      P60603
      Related
      ENSMUSP00000105226.3, ENSMUST00000109597.9
      Conserved Domains (1) summary
      pfam10247
      Location:1479
      Romo1; Reactive mitochondrial oxygen species modulator 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      156144153..156145794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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