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    Ddx17 DEAD box helicase 17 [ Mus musculus (house mouse) ]

    Gene ID: 67040, updated on 14-Sep-2021

    Summary

    Official Symbol
    Ddx17provided by MGI
    Official Full Name
    DEAD box helicase 17provided by MGI
    Primary source
    MGI:MGI:1914290
    See related
    Ensembl:ENSMUSG00000055065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p7; p72; Gm926; C80929; AI047725; 2610007K22Rik; A430025E01Rik
    Summary
    This gene encodes the mouse homolog of human DEAD box polypeptide 17. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). RNA helicases of the DEAD-box family are involved in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 143.7), CNS E14 (RPKM 143.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ddx17 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79411897..79430976, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79527696..79546764, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (79358126..79377171, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41359 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4 Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 Neighboring gene DNA meiotic recombinase 1 Neighboring gene family with sequence similarity 227, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC79147

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables long noncoding RNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pri-miRNA transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX17
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 17
    DEAD box protein 17
    NP_001035277.1
    NP_690019.2
    NP_951061.1
    NP_951062.1
    XP_030104566.1
    XP_036015440.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040187.1NP_001035277.1  probable ATP-dependent RNA helicase DDX17 isoform 4

      See identical proteins and their annotated locations for NP_001035277.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 4).
      Source sequence(s)
      BC096036, CX220180
      Consensus CDS
      CCDS88805.1
      UniProtKB/Swiss-Prot
      Q501J6
      Related
      ENSMUSP00000155307.2, ENSMUST00000229877.2
      Conserved Domains (1) summary
      cl26939
      Location:32500
      DEXDc; DEAD-like helicases superfamily
    2. NM_152806.3NP_690019.2  probable ATP-dependent RNA helicase DDX17 isoform 3

      See identical proteins and their annotated locations for NP_690019.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks most of the exons in the coding region, compared to transcript variant 1. The resulting protein (isoform 3) is much shorter with a different N-terminus when compared to isoform 1.
      Source sequence(s)
      BC038378, CD350507, CX220180
      UniProtKB/TrEMBL
      Q8K392
      Conserved Domains (1) summary
      cd00079
      Location:2260
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    3. NM_199079.2NP_951061.1  probable ATP-dependent RNA helicase DDX17 isoform 2

      See identical proteins and their annotated locations for NP_951061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two coding region segments, uses a different splice site in the 3' coding region, and contains a distinct 3' UTR, compared to transcript variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC117806
      Consensus CDS
      CCDS88804.1
      UniProtKB/Swiss-Prot
      Q501J6
      Related
      ENSMUSP00000155737.2, ENSMUST00000229431.2
      Conserved Domains (1) summary
      cl26939
      Location:32403
      DEXDc; DEAD-like helicases superfamily
    4. NM_199080.2NP_951062.1  probable ATP-dependent RNA helicase DDX17 isoform 1

      See identical proteins and their annotated locations for NP_951062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AK152831, BC038378, BC096036, CX220180
      Consensus CDS
      CCDS27643.1
      UniProtKB/Swiss-Prot
      Q501J6
      UniProtKB/TrEMBL
      Q3U741, Q8K392
      Related
      ENSMUSP00000055535.7, ENSMUST00000054014.9
      Conserved Domains (1) summary
      cl26939
      Location:32502
      DEXDc; DEAD-like helicases superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79411897..79430976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159547.1XP_036015440.1  probable ATP-dependent RNA helicase DDX17 isoform X2

      Conserved Domains (1) summary
      PTZ00110
      Location:1226
      PTZ00110; helicase; Provisional
    2. XM_030248706.1XP_030104566.1  probable ATP-dependent RNA helicase DDX17 isoform X1

      Conserved Domains (1) summary
      PTZ00110
      Location:1228
      PTZ00110; helicase; Provisional

    RNA

    1. XR_004938863.1 RNA Sequence

    2. XR_001781563.3 RNA Sequence

    3. XR_004938862.1 RNA Sequence

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