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    Ddx17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 [ Mus musculus (house mouse) ]

    Gene ID: 67040, updated on 31-Jan-2019

    Summary

    Official Symbol
    Ddx17provided by MGI
    Official Full Name
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 17provided by MGI
    Primary source
    MGI:MGI:1914290
    See related
    Ensembl:ENSMUSG00000055065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p72; Gm926; C80929; AI047725; 2610007K22Rik; A430025E01Rik
    Summary
    This gene encodes the mouse homolog of human DEAD box polypeptide 17. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). RNA helicases of the DEAD-box family are involved in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 143.7), CNS E14 (RPKM 143.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ddx17 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (79527696..79546741, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (79358126..79377171, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41359 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4 Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 Neighboring gene DNA meiotic recombinase 1 Neighboring gene family with sequence similarity 227, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC79147

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    pri-miRNA transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of alternative mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of skeletal muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX17
    Names
    DEAD box protein 17
    NP_001035277.1
    NP_690019.2
    NP_951061.1
    NP_951062.1
    XP_006521353.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040187.1NP_001035277.1  probable ATP-dependent RNA helicase DDX17 isoform 4

      See identical proteins and their annotated locations for NP_001035277.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 4).
      Source sequence(s)
      BC096036, CX220180
      UniProtKB/Swiss-Prot
      Q501J6
      Related
      ENSMUSP00000155307.1, ENSMUST00000229877.1
      Conserved Domains (1) summary
      cl26939
      Location:32500
      DEXDc; DEAD-like helicases superfamily
    2. NM_152806.3NP_690019.2  probable ATP-dependent RNA helicase DDX17 isoform 3

      See identical proteins and their annotated locations for NP_690019.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks most of the exons in the coding region, compared to transcript variant 1. The resulting protein (isoform 3) is much shorter with a different N-terminus when compared to isoform 1.
      Source sequence(s)
      BC038378, CD350507, CX220180
      UniProtKB/TrEMBL
      Q8K392
      Conserved Domains (1) summary
      cd00079
      Location:2260
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    3. NM_199079.2NP_951061.1  probable ATP-dependent RNA helicase DDX17 isoform 2

      See identical proteins and their annotated locations for NP_951061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two coding region segments, uses a different splice site in the 3' coding region, and contains a distinct 3' UTR, compared to transcript variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC117806
      UniProtKB/Swiss-Prot
      Q501J6
      Related
      ENSMUSP00000155737.1, ENSMUST00000229431.1
      Conserved Domains (1) summary
      cl26939
      Location:32403
      DEXDc; DEAD-like helicases superfamily
    4. NM_199080.2NP_951062.1  probable ATP-dependent RNA helicase DDX17 isoform 1

      See identical proteins and their annotated locations for NP_951062.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AK152831, BC038378, BC096036, CX220180
      Consensus CDS
      CCDS27643.1
      UniProtKB/Swiss-Prot
      Q501J6
      UniProtKB/TrEMBL
      Q3U741, Q8K392
      Related
      ENSMUSP00000055535.6, ENSMUST00000054014.8
      Conserved Domains (1) summary
      cl26939
      Location:32502
      DEXDc; DEAD-like helicases superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      79527696..79546741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521290.3XP_006521353.1  probable ATP-dependent RNA helicase DDX17 isoform X1

      Conserved Domains (2) summary
      cd00079
      Location:36168
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:125
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RNA

    1. XR_001781562.1 RNA Sequence

    2. XR_001781563.1 RNA Sequence

    3. XR_384033.2 RNA Sequence

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