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    Mkrn2 makorin, ring finger protein, 2 [ Mus musculus (house mouse) ]

    Gene ID: 67027, updated on 28-Jun-2021

    Summary

    Official Symbol
    Mkrn2provided by MGI
    Official Full Name
    makorin, ring finger protein, 2provided by MGI
    Primary source
    MGI:MGI:1914277
    See related
    Ensembl:ENSMUSG00000000439
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C81377; 2610002L04Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 33.7), adrenal adult (RPKM 19.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mkrn2 in Genome Data Viewer
    Location:
    6; 6 E3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115578844..115598647)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115601883..115621683)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (115551956..115568688)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36355 Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene makorin, ring finger protein 2, opposite strand Neighboring gene v-raf-leukemia viral oncogene 1 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene RIKEN cDNA D830050J10 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    probable E3 ubiquitin-protein ligase makorin-2
    Names
    Makorin RING zinc-finger protein 2
    RING-type E3 ubiquitin transferase makorin-2
    NP_075779.2
    XP_011239733.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023290.3NP_075779.2  probable E3 ubiquitin-protein ligase makorin-2

      See identical proteins and their annotated locations for NP_075779.2

      Status: VALIDATED

      Source sequence(s)
      AC160032
      Consensus CDS
      CCDS39600.1
      UniProtKB/Swiss-Prot
      Q9ERV1
      Related
      ENSMUSP00000000449.8, ENSMUST00000000449.9
      Conserved Domains (3) summary
      smart00356
      Location:3555
      ZnF_C3H1; zinc finger
      PHA03096
      Location:178327
      PHA03096; p28-like protein; Provisional
      cd00162
      Location:238292
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      115578844..115598647
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241431.3XP_011239733.1  probable E3 ubiquitin-protein ligase makorin-2 isoform X1

      Conserved Domains (2) summary
      COG5252
      Location:102175
      COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]
      cd16731
      Location:3794
      RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins
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