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    Oma1 OMA1 zinc metallopeptidase [ Mus musculus (house mouse) ]

    Gene ID: 67013, updated on 23-Oct-2018

    Summary

    Official Symbol
    Oma1provided by MGI
    Official Full Name
    OMA1 zinc metallopeptidaseprovided by MGI
    Primary source
    MGI:MGI:1914263
    See related
    Ensembl:ENSMUSG00000035069 Vega:OTTMUSG00000008073
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPRP-1; ZMPOMA1; 2010001O09Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 2.1), heart adult (RPKM 1.7) and 28 other tissues See more
    Orthologs

    Genomic context

    See Oma1 in Genome Data Viewer
    Location:
    4; 4 C6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (103313209..103371869)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (102986451..103039033)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921539E11 gene Neighboring gene RIKEN cDNA 4930456L15 gene Neighboring gene predicted gene, 36523 Neighboring gene predicted gene 12718 Neighboring gene NADH dehydrogenase (ubiquinone) Fe-S protein 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cristae formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    diet induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    metalloendopeptidase OMA1, mitochondrial
    Names
    OMA1 homolog, zinc metallopeptidase
    overlapping with the m-AAA protease 1 homolog

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025909.3NP_080185.1  metalloendopeptidase OMA1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_080185.1

      Status: PROVISIONAL

      Source sequence(s)
      AL772338
      Consensus CDS
      CCDS18412.1
      UniProtKB/Swiss-Prot
      Q9D8H7
      Related
      ENSMUSP00000045269.3, OTTMUSP00000008428, ENSMUST00000035780.3, OTTMUST00000018318
      Conserved Domains (2) summary
      COG0501
      Location:281451
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam01435
      Location:275449
      Peptidase_M48; Peptidase family M48

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      103313209..103371869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503303.3XP_006503366.1  metalloendopeptidase OMA1, mitochondrial isoform X5

      Conserved Domains (2) summary
      COG0501
      Location:177347
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam01435
      Location:171345
      Peptidase_M48; Peptidase family M48
    2. XM_006503302.3XP_006503365.1  metalloendopeptidase OMA1, mitochondrial isoform X3

      Conserved Domains (2) summary
      COG0501
      Location:281401
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      cl12018
      Location:275402
      Peptidase_M48; Peptidase family M48
    3. XM_006503301.3XP_006503364.1  metalloendopeptidase OMA1, mitochondrial isoform X2

      Conserved Domains (2) summary
      COG0501
      Location:281408
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      cl12018
      Location:275406
      Peptidase_M48; Peptidase family M48
    4. XM_017320360.1XP_017175849.1  metalloendopeptidase OMA1, mitochondrial isoform X4

    5. XM_006503300.3XP_006503363.1  metalloendopeptidase OMA1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006503363.1

      UniProtKB/Swiss-Prot
      Q9D8H7
      Conserved Domains (2) summary
      COG0501
      Location:281451
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam01435
      Location:275449
      Peptidase_M48; Peptidase family M48
    6. XM_006503299.3XP_006503362.1  metalloendopeptidase OMA1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006503362.1

      UniProtKB/Swiss-Prot
      Q9D8H7
      Conserved Domains (2) summary
      COG0501
      Location:281451
      HtpX; Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]
      pfam01435
      Location:275449
      Peptidase_M48; Peptidase family M48

    RNA

    1. XR_867888.1 RNA Sequence

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