Format

Send to:

Choose Destination
    • Showing Current items.

    Oma1 OMA1 zinc metallopeptidase [ Mus musculus (house mouse) ]

    Gene ID: 67013, updated on 16-Aug-2021

    Summary

    Official Symbol
    Oma1provided by MGI
    Official Full Name
    OMA1 zinc metallopeptidaseprovided by MGI
    Primary source
    MGI:MGI:1914263
    See related
    Ensembl:ENSMUSG00000035069
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MPRP-1; ZMPOMA1; 2010001O09Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 2.1), heart adult (RPKM 1.7) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Oma1 in Genome Data Viewer
    Location:
    4; 4 C6
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (103169072..103229066)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (103311875..103371869)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (102986451..103039033)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921539E11 gene Neighboring gene RIKEN cDNA 4930456L15 gene Neighboring gene predicted gene, 36523 Neighboring gene predicted gene 12718 Neighboring gene NADH dehydrogenase (ubiquinone) Fe-S protein 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in HRI-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cristae formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in diet induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in integrated stress response signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrial protein processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial respiratory chain complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autoprocessing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cristae formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in zymogen activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    metalloendopeptidase OMA1, mitochondrial
    Names
    OMA1 homolog, zinc metallopeptidase
    overlapping with the m-AAA protease 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025909.3NP_080185.1  metalloendopeptidase OMA1, mitochondrial precursor

      See identical proteins and their annotated locations for NP_080185.1

      Status: PROVISIONAL

      Source sequence(s)
      AL772338
      Consensus CDS
      CCDS18412.1
      UniProtKB/Swiss-Prot
      Q9D8H7
      Related
      ENSMUSP00000045269.4, ENSMUST00000035780.4
      Conserved Domains (1) summary
      cd07331
      Location:265452
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      103169072..103229066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164357.1XP_036020250.1  metalloendopeptidase OMA1, mitochondrial isoform X6

      Conserved Domains (1) summary
      cd07331
      Location:161305
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase
    2. XM_006503303.5XP_006503366.1  metalloendopeptidase OMA1, mitochondrial isoform X5

      Conserved Domains (1) summary
      cd07331
      Location:161348
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase
    3. XM_006503302.3XP_006503365.1  metalloendopeptidase OMA1, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd07331
      Location:265402
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase
    4. XM_006503301.3XP_006503364.1  metalloendopeptidase OMA1, mitochondrial isoform X2

      Conserved Domains (1) summary
      cd07331
      Location:265409
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase
    5. XM_017320360.1XP_017175849.1  metalloendopeptidase OMA1, mitochondrial isoform X4

      Conserved Domains (1) summary
      cd07331
      Location:265359
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase
    6. XM_030253713.2XP_030109573.1  metalloendopeptidase OMA1, mitochondrial isoform X7

      Conserved Domains (1) summary
      cd07331
      Location:25212
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase
    7. XM_036164359.1XP_036020252.1  metalloendopeptidase OMA1, mitochondrial isoform X8

      Conserved Domains (1) summary
      cd07331
      Location:25169
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase
    8. XM_036164356.1XP_036020249.1  metalloendopeptidase OMA1, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd07331
      Location:265402
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase
    9. XM_006503300.5XP_006503363.1  metalloendopeptidase OMA1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006503363.1

      UniProtKB/Swiss-Prot
      Q9D8H7
      Conserved Domains (1) summary
      cd07331
      Location:265452
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase
    10. XM_030253714.2XP_030109574.1  metalloendopeptidase OMA1, mitochondrial isoform X8

      Conserved Domains (1) summary
      cd07331
      Location:25169
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase
    11. XM_006503299.5XP_006503362.1  metalloendopeptidase OMA1, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006503362.1

      UniProtKB/Swiss-Prot
      Q9D8H7
      Conserved Domains (1) summary
      cd07331
      Location:265452
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase
    12. XM_036164358.1XP_036020251.1  metalloendopeptidase OMA1, mitochondrial isoform X7

      Conserved Domains (1) summary
      cd07331
      Location:25212
      M48C_Oma1_like; Peptidase M48C, integral membrane endopeptidase

    RNA

    1. XR_867888.1 RNA Sequence

    Support Center