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    Mettl6 methyltransferase like 6 [ Mus musculus (house mouse) ]

    Gene ID: 67011, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mettl6provided by MGI
    Official Full Name
    methyltransferase like 6provided by MGI
    Primary source
    MGI:MGI:1914261
    See related
    Ensembl:ENSMUSG00000021891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI467521; AU020711; 1600013P15Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 4.3), CNS E11.5 (RPKM 4.2) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Mettl6 in Genome Data Viewer
    Location:
    14; 14 B
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (31180775..31217007, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31463715..31495059, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (32291984..32308163, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene calpain 7 Neighboring gene SH3-domain binding protein 5 (BTK-associated) Neighboring gene predicted gene, 35907 Neighboring gene PRELI domain-containing protein 2 pseudogene Neighboring gene ELL associated factor 1 Neighboring gene collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2)  1 citation

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA (cytosine-3-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    tRNA N(3)-methylcytidine methyltransferase METTL6
    Names
    methyltransferase-like protein 6
    NP_001346775.1
    NP_001346776.1
    NP_001346777.1
    NP_001346778.1
    NP_001346779.1
    NP_001361702.1
    NP_080183.1
    XP_011243456.1
    XP_030103822.1
    XP_030103823.1
    XP_030103824.1
    XP_030103826.1
    XP_030103828.1
    XP_036014717.1
    XP_036014718.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359846.1NP_001346775.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK005448, AV241644
      Consensus CDS
      CCDS26913.1
      Conserved Domains (1) summary
      pfam08242
      Location:84182
      Methyltransf_12; Methyltransferase domain
    2. NM_001359847.1NP_001346776.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK133735
      Consensus CDS
      CCDS88619.1
      Related
      ENSMUSP00000154767.2, ENSMUST00000227777.2
      Conserved Domains (1) summary
      pfam08242
      Location:84182
      Methyltransf_12; Methyltransferase domain
    3. NM_001359848.1NP_001346777.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK005448, AK006715, AV241644
      Consensus CDS
      CCDS88617.1
      Related
      ENSMUSP00000154580.2, ENSMUST00000227595.2
      Conserved Domains (1) summary
      pfam13649
      Location:70137
      Methyltransf_25; Methyltransferase domain
    4. NM_001359849.1NP_001346778.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK005448, AV241644
      Related
      ENSMUSP00000153931.2, ENSMUST00000228181.2
      Conserved Domains (2) summary
      COG2227
      Location:29124
      UbiG; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]
      pfam08242
      Location:84177
      Methyltransf_12; Methyltransferase domain
    5. NM_001359850.1NP_001346779.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK005448, AV241644
      Conserved Domains (1) summary
      pfam08242
      Location:133231
      Methyltransf_12; Methyltransferase domain
    6. NM_001374773.1NP_001361702.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK078185
      Consensus CDS
      CCDS88618.1
      Related
      ENSMUSP00000154679.2, ENSMUST00000228727.2
      Conserved Domains (1) summary
      pfam08242
      Location:84182
      Methyltransf_12; Methyltransferase domain
    7. NM_025907.4NP_080183.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform 1

      See identical proteins and their annotated locations for NP_080183.1

      Status: VALIDATED

      Source sequence(s)
      AC154616, AK005448, AV241644
      Consensus CDS
      CCDS26913.1
      UniProtKB/Swiss-Prot
      Q8BVH9
      Related
      ENSMUSP00000077138.3, ENSMUST00000055303.5
      Conserved Domains (1) summary
      pfam08242
      Location:84182
      Methyltransf_12; Methyltransferase domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      31180775..31217007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247966.2XP_030103826.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X5

      Conserved Domains (1) summary
      pfam08242
      Location:84182
      Methyltransf_12; Methyltransferase domain
    2. XM_030247968.2XP_030103828.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X6

      Conserved Domains (1) summary
      pfam13649
      Location:70137
      Methyltransf_25; Methyltransferase domain
    3. XM_030247962.2XP_030103822.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X2

      Conserved Domains (1) summary
      pfam08242
      Location:133231
      Methyltransf_12; Methyltransferase domain
    4. XM_036158825.1XP_036014718.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X7

      Conserved Domains (1) summary
      cl17173
      Location:76132
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    5. XM_036158824.1XP_036014717.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X1

      Conserved Domains (1) summary
      pfam08242
      Location:134232
      Methyltransf_12; Methyltransferase domain
    6. XM_030247963.2XP_030103823.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X3

      Conserved Domains (1) summary
      pfam08242
      Location:84182
      Methyltransf_12; Methyltransferase domain
    7. XM_011245154.3XP_011243456.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X3

      Conserved Domains (1) summary
      pfam08242
      Location:84182
      Methyltransf_12; Methyltransferase domain
    8. XM_030247964.2XP_030103824.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X4

      Conserved Domains (1) summary
      pfam08242
      Location:134232
      Methyltransf_12; Methyltransferase domain

    RNA

    1. XR_874361.2 RNA Sequence

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