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    Cisd2 CDGSH iron sulfur domain 2 [ Mus musculus (house mouse) ]

    Gene ID: 67006, updated on 26-Jul-2021

    Summary

    Official Symbol
    Cisd2provided by MGI
    Official Full Name
    CDGSH iron sulfur domain 2provided by MGI
    Primary source
    MGI:MGI:1914256
    See related
    Ensembl:ENSMUSG00000028165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Min; Zcd2; Naf-1; Miner1; Noxp70; AI848398; 1500009M05Rik; 1500026J14Rik; 1500031D15Rik; B630006A20Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 18.0), stomach adult (RPKM 11.7) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cisd2 in Genome Data Viewer
    Location:
    3; 3 G3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (135112173..135129194, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (135406412..135424039, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (135069376..135086397, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46826 Neighboring gene solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2 Neighboring gene solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1 Neighboring gene RIKEN cDNA 4930539J05 gene Neighboring gene ubiquitin-conjugating enzyme E2D 3 Neighboring gene predicted gene, 30992

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 2 iron, 2 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in autophagy of mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in multicellular organism aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CDGSH iron-sulfur domain-containing protein 2
    Names
    mitoNEET-related 1 protein
    nervous system over-expressed protein 70
    nervous system overexpressed protein 70
    nutrient-deprivation autophagy factor-1
    zinc finger, CDGSH-type domain 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025902.3NP_080178.1  CDGSH iron-sulfur domain-containing protein 2

      See identical proteins and their annotated locations for NP_080178.1

      Status: VALIDATED

      Source sequence(s)
      AC156618, BE944243
      Consensus CDS
      CCDS17856.1
      UniProtKB/Swiss-Prot
      Q9CQB5
      Related
      ENSMUSP00000029815.8, ENSMUST00000029815.8
      Conserved Domains (2) summary
      smart00704
      Location:81119
      ZnF_CDGSH; CDGSH-type zinc finger. Function unknown
      pfam10660
      Location:366
      MitoNEET_N; Iron-containing outer mitochondrial membrane protein N-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      135112173..135129194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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