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    Pole4 polymerase (DNA-directed), epsilon 4 (p12 subunit) [ Mus musculus (house mouse) ]

    Gene ID: 66979, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pole4provided by MGI
    Official Full Name
    polymerase (DNA-directed), epsilon 4 (p12 subunit)provided by MGI
    Primary source
    MGI:MGI:1914229
    See related
    Ensembl:ENSMUSG00000030042 AllianceGenome:MGI:1914229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2400007P05Rik; 5830430F06Rik
    Summary
    Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in DNA-templated DNA replication. Predicted to be part of ATAC complex and epsilon DNA polymerase complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.6), CNS E11.5 (RPKM 12.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pole4 in Genome Data Viewer
    Location:
    6 C3; 6 35.94 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (82593513..82629985, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (82616532..82653043, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53289 Neighboring gene STARR-seq mESC enhancer starr_16425 Neighboring gene tachykinin receptor 1 Neighboring gene STARR-seq mESC enhancer starr_16429 Neighboring gene STARR-positive B cell enhancer ABC_E6445 Neighboring gene STARR-seq mESC enhancer starr_16430 Neighboring gene STARR-seq mESC enhancer starr_16435 Neighboring gene predicted gene, 32425 Neighboring gene predicted gene, 32534

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of epsilon DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of epsilon DNA polymerase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    DNA polymerase epsilon subunit 4
    Names
    DNA polymerase II subunit 4
    DNA polymerase epsilon subunit p12
    NP_001357224.1
    NP_080158.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370295.1NP_001357224.1  DNA polymerase epsilon subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159655
      Conserved Domains (1) summary
      COG5208
      Location:38113
      HAP5; CCAAT-binding factor, subunit C [Transcription]
    2. NM_025882.3NP_080158.1  DNA polymerase epsilon subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_080158.1

      Status: VALIDATED

      Source sequence(s)
      AC159655
      Consensus CDS
      CCDS39524.1
      UniProtKB/Swiss-Prot
      Q3TJ13, Q9CQ36
      UniProtKB/TrEMBL
      E0CYA9
      Related
      ENSMUSP00000093462.6, ENSMUST00000095786.6
      Conserved Domains (1) summary
      cl23735
      Location:41104
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      82593513..82629985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003956251.2 RNA Sequence