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    Pole4 polymerase (DNA-directed), epsilon 4 (p12 subunit) [ Mus musculus (house mouse) ]

    Gene ID: 66979, updated on 22-Aug-2021

    Summary

    Official Symbol
    Pole4provided by MGI
    Official Full Name
    polymerase (DNA-directed), epsilon 4 (p12 subunit)provided by MGI
    Primary source
    MGI:MGI:1914229
    See related
    Ensembl:ENSMUSG00000030042
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2400007P05Rik; 5830430F06Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 15.6), CNS E11.5 (RPKM 12.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pole4 in Genome Data Viewer
    Location:
    6; 6 C3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (82593513..82629985, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (82616532..82653043, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (82596706..82602859, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53289 Neighboring gene tachykinin receptor 1 Neighboring gene predicted gene, 32425 Neighboring gene predicted gene, 32534

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of epsilon DNA polymerase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA polymerase epsilon subunit 4
    Names
    DNA polymerase II subunit 4
    DNA polymerase epsilon subunit p12
    NP_001357224.1
    NP_080158.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370295.1NP_001357224.1  DNA polymerase epsilon subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159655
      Conserved Domains (1) summary
      COG5208
      Location:38113
      HAP5; CCAAT-binding factor, subunit C [Transcription]
    2. NM_025882.3NP_080158.1  DNA polymerase epsilon subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_080158.1

      Status: VALIDATED

      Source sequence(s)
      AC159655
      Consensus CDS
      CCDS39524.1
      UniProtKB/Swiss-Prot
      Q9CQ36
      Related
      ENSMUSP00000093462.6, ENSMUST00000095786.6
      Conserved Domains (1) summary
      cl23735
      Location:41104
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      82593513..82629985 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003956251.2 RNA Sequence

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